Uses
ChemicalBook > CAS DataBase List > OSS-128167

OSS-128167

Uses
Product Name
OSS-128167
CAS No.
887686-02-4
Chemical Name
OSS-128167
Synonyms
SIRT6-IN-1;OSS-128167;OSS_128167 ，S8627;OSS-128167(SIRT6-IN-1);OSS_128167, 10 mM in DMSO;OSS-128167;OSS 128167;OSS128167;5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid;Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-;SIRT6,deacetylase,OSS_128167,TNF-α,immune,antiviral,inhibit,PPARα,H3K9,Sirtuin,acetylation,anti-cancer,Hepatitis B virus,Inhibitor,diabetes,GLUT-1,chemosensitization,HBV
CBNumber
CB63373071
Molecular Formula
C19H14N2O6
Formula Weight
366.32
MOL File
887686-02-4.mol
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OSS-128167 Property

storage temp. 
2-8°C
solubility 
DMSO (Slightly)
form 
Solid
color 
Red to Very Dark Brown
InChI
InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
InChIKey
HTJWLEGCECXGSQ-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(NC(=O)C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=CC=C1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3957
Product name
OSS_128167
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$75.05
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3957
Product name
OSS_128167
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$319
Updated
2025/07/31
Cayman Chemical
Product number
29052
Product name
OSS-128167
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29052
Product name
OSS-128167
Packaging
25mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
29052
Product name
OSS-128167
Packaging
5mg
Price
$139
Updated
2024/03/01
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OSS-128167 Chemical Properties,Usage,Production

Uses

OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects.

Uses

OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects

Biological Activity

eCll penetrant, potent and selective inhibitor of SIRT6.



OSS_128167 is a cell penetrant, potent and selective inhibitor of SIRT6 (Sirtuin 6) th at exhibits anti-cancer, anti-inflammatory, and anti-viral properties. OSS_128167 inhibits HBV transcription and replication through upregulating peroxisome proliferator-activated receptors α (PPARα) expression.

in vivo

OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice[2].

Animal Model:Male HBV transgenic mice (6-8-week-old)[2]
Dosage:50 mg/kg
Administration:Intraperitoneal injection; every 4 days; for 12 days
Result:The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.

IC 50

SIRT6: 89 μM (IC50); SIRT2: 751 μM (IC50); SIRT1: 1578 μM (IC50); HBV

OSS-128167 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSS-128167 Suppliers

China 76 United States 10 USA 1 Global 87

887686-02-4, OSS-128167Related Search:


  • OSS-128167;OSS 128167;OSS128167
  • OSS-128167(SIRT6-IN-1)
  • OSS-128167
  • SIRT6-IN-1
  • Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-
  • 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
  • SIRT6,deacetylase,OSS_128167,TNF-α,immune,antiviral,inhibit,PPARα,H3K9,Sirtuin,acetylation,anti-cancer,Hepatitis B virus,Inhibitor,diabetes,GLUT-1,chemosensitization,HBV
  • OSS_128167, 10 mM in DMSO
  • OSS_128167 ，S8627
  • 887686-02-4
  • API