Bromo-PEG3-CH2CO2tBu
- Product Name
- Bromo-PEG3-CH2CO2tBu
- CAS No.
- 2100306-71-4
- Chemical Name
- Bromo-PEG3-CH2CO2tBu
- Synonyms
- tert-butyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate;Br-PEG3-CH2-Boc;Br-PEG3-CH2COOtBu;Bromo-PEG3-CH2-Boc;Bromo-PEG3-CH2CO2tBu;t-butyl acetate-PEG3-bromide BROMO-PEG3-CH2CO2TBU;Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester;Br-PEG3-CH2COOtBu/Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB63373596
- Molecular Formula
- C12H23BrO5
- Formula Weight
- 327.21
- MOL File
- 2100306-71-4.mol
Bromo-PEG3-CH2CO2tBu Property
- Boiling point:
- 360.9±27.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS104005
- Product name
- Br-PEG3-CH2COOtBu
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- BP-23572
- Product name
- Bromo-PEG3-CH2CO2tBu
- Purity
- 98%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- AS104005
- Product name
- Br-PEG3-CH2COOtBu
- Purity
- 95+%
- Packaging
- 1g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- AS104005
- Product name
- Br-PEG3-CH2COOtBu
- Purity
- 95+%
- Packaging
- 5G
- Price
- $1613
- Updated
- 2021/12/16
- Product number
- B-0863
- Product name
- Br-PEG3-CH2COOtBu
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $201.66
- Updated
- 2021/12/16
Bromo-PEG3-CH2CO2tBu Chemical Properties,Usage,Production
Description
Bromo-PEG3-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bromo-PEG3-CH2CO2tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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