PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

Product Name: PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
CAS No.: 54784-44-0
Chemical Name: PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
Synonyms: wy-18,185;LHRH, Phe(2)-Ala(6)-;[D-PHE2, D-ALA6]-LH-RH;[D-PHE2, D-ALA6]-LH-RH (HUMAN);(d-phe(sup2))-(d-ala(sup6))-lhrh;D-PHE2 D-ALA6-LUTEINIZING HORMONE &;GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2;PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2;PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2;D-phe2,D-ala6-luteinizing hormone*releasing hormo
CBNumber: CB6337481
Molecular Formula: C59H79N15O13
Formula Weight: 1206.35
MOL File: 54784-44-0.mol

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PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Property

storage temp.: −20°C

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Safety

Hazard Codes: T
Risk Statements: 60
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: OK6600000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0005623
Product name: PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
Purity: 95.00%
Packaging: 5MG
Price: $497.77
Updated: 2021/12/16

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PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Chemical Properties,Usage,Production

Uses

[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].

in vivo

[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats^[1].
[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity^[2]. [D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old^[3].
[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone^[4].

Animal Model:	Adult female Sprague-Dawley rats (200-250 g)^[2]
Dosage:	1 mg/rat
Administration:	SC injections, from 12:00 to 14:30 hr on the day of proestrus
Result:	Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.

References

[1] Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. DOI:10.3109/07435807609056903
[2] Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. DOI:10.1021/jm00246a016
[3] Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. DOI:10.1210/endo-98-1-247
[4] Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23. DOI:10.3109/07435807509053836

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Preparation Products And Raw materials

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Preparation Products

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PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Suppliers

China 9 Switzerland 1 Ukraine 1 United States 3 Global 14

GL Biochem (Shanghai) Ltd

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54784-44-0, PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2Related Search:

H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

(d-phe(sup2))-(d-ala(sup6))-lhrh

(d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormon

(d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormone

2-d-phenylalanine-6-d-alanine-luteinizinghormone-releasinghormone(pig

wy-18,185

D-phe2,D-ala6-luteinizing hormone*releasing hormo

D-PHE2 D-ALA6-LUTEINIZING HORMONE &

LHRH, Phe(2)-Ala(6)-

GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2

[D-PHE2, D-ALA6]-LH-RH

[D-PHE2, D-ALA6]-LH-RH (HUMAN)

[DPHE2,DALA6] LUTEINIZING HORMONE-RELEASING HORMONE

[D-PHE2, D-ALA6]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

[D-Phe2,D-Ala6]lutenizing hormone-releasing factor

5-Oxo-L-Pro-D-Phe-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-Gly-NH2

GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2: GLP-DF-WSY-DA-LRPG-NH2

Glycinamide, 5-oxo-L-prolyl-D-phenylalanyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl-L-prolyl-

54784-44-0

C59H79N15O13

BioChemical

Amino Acids and Peptides

Biochemicals and Reagents

LH-RH

Peptides

Releasing Factors