LX-2343
- Product Name
- LX-2343
- CAS No.
- 333745-53-2
- Chemical Name
- LX-2343
- Synonyms
- LX-2343;LX-2343 (LX2343);LX2343, 10 mM in DMSO;LX2343;LX-2343;LX 2343;2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide;Acetamide, N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-;N-(Benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide;Autophagy,PI3K,Amyloid-β,Inhibitor,β-Secretase,Beta-secretase,LX-2343,LX2343,inhibit,BACE,Phosphoinositide 3-kinase,β-amyloid peptide,LX 2343,Abeta
- CBNumber
- CB63374896
- Molecular Formula
- C22H19ClN2O6S
- Formula Weight
- 474.91
- MOL File
- 333745-53-2.mol
LX-2343 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:73.33(Max Conc. mg/mL);154.41(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);69.49(Max Conc. mM) - form
- A solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 27799
- Product name
- LX2343
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 27799
- Product name
- LX2343
- Packaging
- 10mg
- Price
- $310
- Updated
- 2024/03/01
- Product number
- 27799
- Product name
- LX2343
- Packaging
- 5mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- L395005
- Product name
- LX-2343
- Packaging
- 5mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CS-0040305
- Product name
- LX2343
- Purity
- 99.80%
- Packaging
- 100mg
- Price
- $850
- Updated
- 2021/12/16
LX-2343 Chemical Properties,Usage,Production
Uses
LX-2343, is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. It has also shown activity as a non-ATP competitive PI3K inhibitor. LX2343 stimulates autophagy in its promotion of Aβ clearance.
in vivo
APP/PS1 mice express chimeric human Swedish mutant APP and a mutant human presenilin 1 protein and are widely used as an effective animal model for AD dementia. The amelioration of memory impairment by LX2343 is evaluated t in this model using the MWM test. In 8-d training trials, the path lengths and escape latencies used to find the platform for APP/PS1 transgenic mice are remarkably longer than those for non-transgenic mice, while 10 mg/kg LX2343 administration obviously antagonizes the prolonged path lengths and escape latencies at d 7 and 8. In the probe trial assay, the LX2343-administered transgenic mice cross over the hidden location of the platform more frequently compared with the vehicle-administered transgenic mice[1].
IC 50
BACE1: 11.43 μM (IC50); PI3K: 15.99 μM (IC50); Aβ; Autophagy
LX-2343 Preparation Products And Raw materials
Raw materials
Preparation Products
LX-2343 Suppliers
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