ChemicalBook > CAS DataBase List > LX-2343

LX-2343

Product Name
LX-2343
CAS No.
333745-53-2
Chemical Name
LX-2343
Synonyms
LX-2343;LX-2343 (LX2343);LX2343, 10 mM in DMSO;LX2343;LX-2343;LX 2343;2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide;Acetamide, N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-;N-(Benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide;Autophagy,PI3K,Amyloid-β,Inhibitor,β-Secretase,Beta-secretase,LX-2343,LX2343,inhibit,BACE,Phosphoinositide 3-kinase,β-amyloid peptide,LX 2343,Abeta
CBNumber
CB63374896
Molecular Formula
C22H19ClN2O6S
Formula Weight
474.91
MOL File
333745-53-2.mol
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LX-2343 Property

storage temp. 
Store at -20°C
solubility 
DMSO:73.33(Max Conc. mg/mL);154.41(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);69.49(Max Conc. mM)
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27799
Product name
LX2343
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
27799
Product name
LX2343
Packaging
10mg
Price
$310
Updated
2024/03/01
Cayman Chemical
Product number
27799
Product name
LX2343
Packaging
5mg
Price
$168
Updated
2024/03/01
TRC
Product number
L395005
Product name
LX-2343
Packaging
5mg
Price
$275
Updated
2021/12/16
ChemScene
Product number
CS-0040305
Product name
LX2343
Purity
99.80%
Packaging
5mg
Price
$120
Updated
2021/12/16
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LX-2343 Chemical Properties,Usage,Production

Uses

LX-2343, is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. It has also shown activity as a non-ATP competitive PI3K inhibitor. LX2343 stimulates autophagy in its promotion of Aβ clearance.

in vivo

APP/PS1 mice express chimeric human Swedish mutant APP and a mutant human presenilin 1 protein and are widely used as an effective animal model for AD dementia. The amelioration of memory impairment by LX2343 is evaluated t in this model using the MWM test. In 8-d training trials, the path lengths and escape latencies used to find the platform for APP/PS1 transgenic mice are remarkably longer than those for non-transgenic mice, while 10 mg/kg LX2343 administration obviously antagonizes the prolonged path lengths and escape latencies at d 7 and 8. In the probe trial assay, the LX2343-administered transgenic mice cross over the hidden location of the platform more frequently compared with the vehicle-administered transgenic mice[1].

IC 50

BACE1: 11.43 μM (IC50); PI3K: 15.99 μM (IC50); Aβ; Autophagy

LX-2343 Preparation Products And Raw materials

Raw materials

Preparation Products

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LX-2343 Suppliers

China 58 United States 7 Global 65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

333745-53-2, LX-2343Related Search:


  • LX-2343
  • LX2343;LX-2343;LX 2343
  • Acetamide, N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-
  • 2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide
  • Autophagy,PI3K,Amyloid-β,Inhibitor,β-Secretase,Beta-secretase,LX-2343,LX2343,inhibit,BACE,Phosphoinositide 3-kinase,β-amyloid peptide,LX 2343,Abeta
  • N-(Benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide
  • LX2343, 10 mM in DMSO
  • LX-2343 (LX2343)
  • 333745-53-2