IDF-11774
- Product Name
- IDF-11774
- CAS No.
- 1429054-28-3
- Chemical Name
- IDF-11774
- Synonyms
- CS-2820;IDF-11774;IDF 11774;IDF11774;IDF-11774, 10 mM in DMSO;2-[4-(1-adamantyl)phenoxy]-1-(4-methylpiperazin-1-yl)ethanone;2-(4-(Adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethanone;Ethanone, 1-(4-methyl-1-piperazinyl)-2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)-;IDF 11774,inhibit,HIF-PH,IDF-11774,Hypoxia-inducible factors,HIFs,IDF11774,Inhibitor,HIF/HIF Prolyl-Hydroxylase
- CBNumber
- CB63376108
- Molecular Formula
- C23H32N2O2
- Formula Weight
- 368.51
- MOL File
- 1429054-28-3.mol
IDF-11774 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 60 mg/mL (162.82 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I165005
- Product name
- IDF-11774
- Packaging
- 2.5mg
- Price
- $635
- Updated
- 2021/12/16
- Product number
- CS-0040309
- Product name
- IDF-11774
- Purity
- 95.37%
- Packaging
- 50mg
- Price
- $740
- Updated
- 2021/12/16
- Product number
- orb611277
- Product name
- IDF-11774
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
- Product number
- CS-0040309
- Product name
- IDF-11774
- Purity
- 95.37%
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0040309
- Product name
- IDF-11774
- Purity
- 95.37%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
IDF-11774 Chemical Properties,Usage,Production
Uses
IDF-11774, is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM in cancer cell line. It has shown to reduce capillary network formation on Matrigel, when human umbilical vascular endothelial cells (HUVECs) were treated with IDF-11774.
in vivo
Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model[1].
IDF-11774 Preparation Products And Raw materials
Raw materials
Preparation Products
IDF-11774 Suppliers
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