ChemicalBook > CAS DataBase List > (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

Product Name: (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
CAS No.: 1672662-14-4
Chemical Name: (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Synonyms: PT2339;PT2399 ，S8351;PT2399, 10 mM in DMSO;PT2399;PT 2399;PT-2399;3-[(1S)-7-(Difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-indan-4-yl]oxy-5-fluoro-benzonitrile;Hypoxia-inducible factors,Inhibitor,PT2399,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIFs,PT-2399,PT 2399;(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile;Benzonitrile, 3-[[(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-2,3-dihydro-1-hydroxy-1H-inden-4-yl]oxy]-5-fluoro-
CBNumber: CB63376911
Molecular Formula: C17H10F5NO4S
Formula Weight: 419.32
MOL File: 1672662-14-4.mol

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(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Property

Boiling point:: 516.0±50.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
storage temp.: Store at -20°C, stored under nitrogen
solubility: DMSO : ≥ 200 mg/mL (476.96 mM)
pka: 11.30±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030117
Product name: PT2399
Purity: 99.88%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0009235
Product name: PT-2399
Purity: 95.00%
Packaging: 5MG
Price: $451.36
Updated: 2021/12/16

ChemScene

Product number: CS-0030117
Product name: PT2399
Purity: 99.88%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0030117
Product name: PT2399
Purity: 99.88%
Packaging: 50mg
Price: $2250
Updated: 2021/12/16

ChemScene

Product number: CS-0030117
Product name: PT2399
Purity: 99.88%
Packaging: 100mg
Price: $3350
Updated: 2021/12/16

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(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Chemical Properties,Usage,Production

Biological Activity

PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo[1][2][3]. PT2399 (compound 10f) inhibits HIF-2α with an IC50 of 6 nM[3]. PT2399 can bind directly to the HIF-2α PAS B domain, and cripple HIF-2α's ability to bind to Aryl hydrocarbon receptor nuclear translocator (ARNT)[2].PT2399 (20 μM) causes off-target toxicity because it inhibits the proliferation of HIF-2α -/- 786-O cells and other cancer cell lines with undetectable HIF-2α[2]. PT2399 (0.2-2 μM; 0-21 days) inhibits 786-O cells soft agar growth[2].PT2399 represses various HIF target genes in 786-O VHL-/- ccRCC cells, does not suppress HIF-1α-specific targets such as BNIP3[2]. PT2399 inhibits tumor cell proliferation 3.5 fold in renal cell carcinoma (RCC) bearing mice[1].PT2399 reduces tumor cell density and increases fibrosis in RCC bearing mice[1].PT2399 (100 mg/kg; oral gavage; every 12 hours) is more active than SU 11248, and inhibits tumor growth in several SU 11248-resistant tumors in RCC bearing mice [1].PT2399 directly inhibits HIF-2α causes tumor regression in preclinical models of primary and metastatic pVHL-defective ccRCC in an on-target fashion[2].

References

[1]. Chen W, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016 Nov 3;539(7627):112-117.[2]. Cho H, et al. On-Target Efficacy of a HIF2α Antagonist in Preclinical Kidney Cancer Models. Nature. Nature. 2016 Nov 3;539(7627):107-111.[3]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.

(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1672662-14-4, (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrileRelated Search:

(S)-(+)-3-METHYL-2-BUTANOL (-)-Blebbistatin (S)-3,3-DIMETHYL-2-BUTANOL (S)-3,3,3-Trifluoropropane-1,2-diol (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (S)-3-NITROPHENETHYLAMINE HCL 3-BUTENE-1,2-DIOL

(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

PT2399;PT 2399;PT-2399

Benzonitrile, 3-[[(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-2,3-dihydro-1-hydroxy-1H-inden-4-yl]oxy]-5-fluoro-

Hypoxia-inducible factors,Inhibitor,PT2399,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIFs,PT-2399,PT 2399

PT2339

PT2399, 10 mM in DMSO

3-[(1S)-7-(Difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-indan-4-yl]oxy-5-fluoro-benzonitrile

PT2399 ，S8351

1672662-14-4