CL2-SN38

Product Name: CL2-SN38
CAS No.: 1036969-20-6
Chemical Name: CL2-SN38
Synonyms: CS-2807;CL2-SN38;CL2-SN-38(DCA);L-Lysinamide, N-[32-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,5-dioxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacont-1-yl]-L-phenylalanyl-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,...
CBNumber: CB63379932
Molecular Formula: C82H106N12O23
Formula Weight: 1627.81
MOL File: 1036969-20-6.mol

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CL2-SN38 Property

Density: 1.38±0.1 g/cm3(Predicted)
solubility: DMSO: >1 mg/ml
Ethanol: >1 mg/ml
pka: 9.12±0.40(Predicted)
form: Solid
color: Light yellow to green yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0102763
Product name: CL2-SN-38
Purity: 98.68%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0102763
Product name: CL2-SN-38
Purity: 98.68%
Packaging: 25mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0102763
Product name: CL2-SN-38
Purity: 98.68%
Packaging: 50mg
Price: $1000
Updated: 2021/12/16

ChemScene

Product number: CS-0102763
Product name: CL2-SN-38
Purity: 98.68%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

DC Chemicals

Product number: 025861
Product name: CL2-SN-38(DCA)
Packaging: 002
Price: $2200
Updated: 2021/12/16

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CL2-SN38 Chemical Properties,Usage,Production

Uses

CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer[1].

IC 50

Camptothecins

References

[1] Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. DOI:10.1158/1078-0432.CCR-10-2939
[2] SUNG-JU MOON. Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy[J]. Journal of Medicinal Chemistry, 2008, 51 21: 6916-6926. DOI: 10.1021/jm800719t

CL2-SN38 Preparation Products And Raw materials

Raw materials

Preparation Products

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CL2-SN38 Suppliers

China 22 United States 4 Global 26

Shanghai Chaolan Chemical Technology Center

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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Shanghai Haoyuan Chemexpress Co., Ltd.

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Nanchang Tianzhen Biotechnology Co., Ltd

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Chunchuang (Wuhan) Technology Co., Ltd

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1036969-20-6, CL2-SN38Related Search:

CL2-SN38

CS-2807

L-Lysinamide, N-[32-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,5-dioxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacont-1-yl]-L-phenylalanyl-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,...

CL2-SN-38(DCA)

1036969-20-6

C82H106N12O23

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