ChemicalBook > CAS DataBase List > 5-BROMO-2-CHLORO-BENZOYL CHLORIDE

5-BROMO-2-CHLORO-BENZOYL CHLORIDE

Product Name
5-BROMO-2-CHLORO-BENZOYL CHLORIDE
CAS No.
21900-52-7
Chemical Name
5-BROMO-2-CHLORO-BENZOYL CHLORIDE
Synonyms
Dapagliflozin Impurity 70;Dapagliflozin Impurity 55;Dapagliflozin Impurity N50;Dapagliflozin Impurity 70 CRS;5-BROMO-2-CHLORO-BENZOYL CHLORIDE;Benzoyl chloride, 5-bromo-2-chloro-
CBNumber
CB6346795
Molecular Formula
C7H3BrCl2O
Formula Weight
253.91
MOL File
Mol file
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5-BROMO-2-CHLORO-BENZOYL CHLORIDE Property

Boiling point:
281.4±25.0 °C(Predicted)
Density 
1.763±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Safety

RIDADR 
UN1759
HazardClass 
8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B680522
Product name
5-Bromo-2-chlorobenzoylChloride
Packaging
250mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
435330
Product name
5-Bromo-2-chlorobenzoyl Chloride
Packaging
250mg
Price
$305
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB76146
Product name
5-Bromo-2-chlorobenzoyl chloride
Packaging
500mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB76146
Product name
5-Bromo-2-chlorobenzoyl chloride
Packaging
1g
Price
$320
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB76146
Product name
5-Bromo-2-chlorobenzoyl chloride
Packaging
2g
Price
$380
Updated
2021/12/16
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5-BROMO-2-CHLORO-BENZOYL CHLORIDE Chemical Properties,Usage,Production

Uses

5-Bromo-2-chlorobenzoyl Chloride is an intermediate in the synthesis of labelled and unlabelled isotopes of glucuronide metabolites of dapagliflozin. It also functions as an intermediate in the synthesis of dapagliflozin, a potent and selective hSGLT2 inhibitor.

Synthesis

21739-92-4

21900-52-7

Step 1. 5-Bromo-2-chlorobenzoic acid (100 g, 0.43 mol) was dissolved in 500 mL of dichloromethane and 1 g of pyridine was added as a catalyst. Thionyl chloride (60.5 g, 0.51 mol) was added slowly and dropwise at room temperature, followed by heating the reaction mixture to 40 °C and refluxing for 3.5 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, dichloromethane was removed by distillation under reduced pressure to afford 104 g of 5-bromo-2-chlorobenzoyl chloride (yield: 97%), which can be used directly in the next step of the reaction without further purification.

References

[1] Patent: US2004/138439, 2004, A1. Location in patent: Page 18
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1236 - 1251
[3] Patent: WO2015/43511, 2015, A1. Location in patent: Paragraph 00227
[4] Patent: CN106892948, 2017, A. Location in patent: Paragraph 0269; 0270; 0271
[5] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0013

5-BROMO-2-CHLORO-BENZOYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-CHLORO-BENZOYL CHLORIDE Suppliers

China 72 Germany 1 India 2 United Kingdom 5 United States 8 USA 1 Global 89
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View Lastest Price from 5-BROMO-2-CHLORO-BENZOYL CHLORIDE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dapagliflozin Impurity 55
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dapagliflozin Impurity 55
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-13

21900-52-7, 5-BROMO-2-CHLORO-BENZOYL CHLORIDERelated Search:

Benzoyl chloride

  • 5-BROMO-2-CHLORO-BENZOYL CHLORIDE
  • Benzoyl chloride, 5-bromo-2-chloro-
  • Dapagliflozin Impurity 55
  • Dapagliflozin Impurity 70
  • Dapagliflozin Impurity 70 CRS
  • Dapagliflozin Impurity N50
  • 21900-52-7
  • C7H3BrCl2O