ChemicalBook > CAS DataBase List > 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE

7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE

Product Name
7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE
CAS No.
62458-96-2
Chemical Name
7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE
Synonyms
7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyriMidin-4-ol;7-benzyl-5;4-d]pyriMidin-4(4aH)-one;7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H);7-benzyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyriMidin-4-one;7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;5,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidin-4(;7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one;7-Benzyl-5,6,7,8-tetrahydro-4aH-pyrido[3,4-d]pyrimidin-4-one;7-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONE HCL
CBNumber
CB6355377
Molecular Formula
C14H15N3O
Formula Weight
241.29
MOL File
62458-96-2.mol
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7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE Property

Melting point:
198 °C
Boiling point:
406.5±55.0 °C(Predicted)
Density 
1.27
storage temp. 
Sealed in dry,Room Temperature
pka
7.77±0.20(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C14H15N3O/c18-14-12-6-7-17(9-13(12)15-10-16-14)8-11-4-2-1-3-5-11/h1-5,10H,6-9H2,(H,15,16,18)
InChIKey
NBOPLUXBZUJFHI-UHFFFAOYSA-N
SMILES
C1NC(=O)C2CCN(CC3=CC=CC=C3)CC=2N=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
W7448
Product name
7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one
Packaging
250mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB150834
Product name
7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-oneHydrochloride
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB150834
Product name
7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-oneHydrochloride
Packaging
250mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB150834
Product name
7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-oneHydrochloride
Packaging
500mg
Price
$260
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB150834
Product name
7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-oneHydrochloride
Packaging
1g
Price
$453
Updated
2021/12/16
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7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

3473-63-0

52763-21-0

62458-96-2

To a mixed solution of sodium methanolate (25 wt% methanol solution, 67.6 mL, 296 mmol) and methanol (70 mL) was sequentially added formamidine acetate (11.00 g, 106 mmol) and ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (25.16 g, 84 mmol) at 25 °C. The reaction mixture was stirred continuously at 25°C for 20 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, water (90 mL) was added followed by slow dropwise addition of acetic acid (6.05 mL, 106 mmol) and stirring was continued at 25 °C for 3 hours. Most of the methanol was removed by distillation under reduced pressure and the reaction mixture was concentrated. The resulting suspension was filtered and the solid product was collected, washed with water and dried under vacuum to afford 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (16.10 g, 79% yield) as a white solid.LC/MS analysis showed: m/z 242.06 ([M+H]+), retention time 0.598 min (Method 12). .1H-NMR (500 MHz, CDCl3) δ 12.61 (broad single peak, 1H), 7.99 (single peak, 1H), 7.38-7.26 (multiple peaks, 5H), 3.73 (multiple peaks, 2H), 3.50 (multiple peaks, 2H), 2.74 (multiple peaks, 2H), 2.66 (multiple peaks, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 160 - 167
[2] Patent: WO2009/158396, 2009, A1. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 18, p. 5019 - 5024
[4] Patent: US2008/275052, 2008, A1. Location in patent: Page/Page column 45

7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE Suppliers

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View Lastest Price from 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE 62458-96-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Career Henan Chemical Co
Product
7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE 62458-96-2
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200KG
Release date
2019-08-30

62458-96-2, 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDERelated Search:

Tetryzoline 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE 1-BENZYL-4-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

  • 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE
  • 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one
  • 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one
  • 5,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidin-4(4aH)-one
  • 4-d]pyriMidin-4(4aH)-one
  • 7-benzyl-5
  • 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyriMidin-4-ol
  • 7-benzyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyriMidin-4-one
  • 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyriMidin-4(3H)-one hydrochloride
  • 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)
  • 5,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidin-4(
  • Pyrido[3,4-d]pyrimidin-4(4aH)-one, 5,6,7,8-tetrahydro-7-(phenylmethyl)-
  • 7-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONE HCL
  • Pyrido[3,4-d]pyrimidin-4(3H)-one,5,6,7,8-tetrahydro-7-(phenylmethyl)-
  • 7-Benzyl-5,6,7,8-tetrahydro-4aH-pyrido[3,4-d]pyrimidin-4-one
  • 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE ISO 9001：2015 REACH
  • 62458-96-2
  • MFCD08458225 oldold
  • 1053656-41-9 oldold
  • CHIRAL CHEMICALS