AZTSBAWJROLRIQ-LESCRADOSA-N

Product Name: AZTSBAWJROLRIQ-LESCRADOSA-N
CAS No.: 135383-55-0
Chemical Name: AZTSBAWJROLRIQ-LESCRADOSA-N
Synonyms: AZTSBAWJROLRIQ-LESCRADOSA-N;Monomethyl auristatin E intermediate-7;(3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate;tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate;tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate;Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)
CBNumber: CB63586745
Molecular Formula: C20H31NO5
Formula Weight: 365.46
MOL File: 135383-55-0.mol

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AZTSBAWJROLRIQ-LESCRADOSA-N Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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AZTSBAWJROLRIQ-LESCRADOSA-N Chemical Properties,Usage,Production

Uses

Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

References

[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931

AZTSBAWJROLRIQ-LESCRADOSA-N Preparation Products And Raw materials

Raw materials

Preparation Products

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AZTSBAWJROLRIQ-LESCRADOSA-N Suppliers

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135383-55-0, AZTSBAWJROLRIQ-LESCRADOSA-NRelated Search:

AZTSBAWJROLRIQ-LESCRADOSA-N

(3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate

Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)

tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate

tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate

Monomethyl auristatin E intermediate-7

135383-55-0