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DECAMETHONIUM BROMIDE

Product Name
DECAMETHONIUM BROMIDE
CAS No.
541-22-0
Chemical Name
DECAMETHONIUM BROMIDE
Synonyms
decacuran;syncurine;dekamethoniumbromid;DECAMETHONIUM BROMIDE;decamethoniumdibromide;Decamethonium Bromide >Decamethonium bromide ,98%;Decamethonium Bromide, ≥ 98.0%;DECAMETHONIUM BROMIDE USP/EP/BP;DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE)
CBNumber
CB6360047
Molecular Formula
C16H38Br2N2
Formula Weight
418.29
MOL File
541-22-0.mol
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DECAMETHONIUM BROMIDE Property

Melting point:
263-267 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
crystalline
color 
off-white
Water Solubility 
almost transparency
λmax
λ: 240 nm Amax: 0.04
λ: 250 nm Amax: 0.03
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02
Merck 
14,2847
BRN 
3728288
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
541-22-0(CAS DataBase Reference)
EPA Substance Registry System
Decamethonium dibromide (541-22-0)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
BP5950000
F 
3-10
HS Code 
2923.90.0100
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in mouse: 190mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1260
Product name
Decamethonium bromide
Purity
crystalline
Packaging
5g
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
D1260
Product name
Decamethonium bromide
Purity
crystalline
Packaging
10g
Price
$239
Updated
2024/03/01
TCI Chemical
Product number
D1314
Product name
Decamethonium Bromide
Purity
>98.0%(T)
Packaging
5g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
D1314
Product name
Decamethonium Bromide
Purity
>98.0%(T)
Packaging
25g
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
24907
Product name
Decamethonium (bromide)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
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DECAMETHONIUM BROMIDE Chemical Properties,Usage,Production

Description

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.

Chemical Properties

crystalline solid

Uses

antipsychotic

brand name

Syncurine (GlaxoSmithKline).

Biological Functions

Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.

General Description

Crystals derived from methanol and acetone.

Air & Water Reactions

Water soluble.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.

Fire Hazard

Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

DECAMETHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DECAMETHONIUM BROMIDE manufacturers

Dideu Industries Group Limited
Product
DECAMETHONIUM BROMIDE 541-22-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-07
Career Henan Chemical Co
Product
DECAMETHONIUM BROMIDE 541-22-0
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

541-22-0, DECAMETHONIUM BROMIDERelated Search:

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  • 1,10-Decanediaminium,N,N,N,N’,N’,N’-hexamethyl-,dibromide
  • 10-decanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide
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  • decamethylene-1,10-bistrimethylammoniumdibromide
  • decamethylenebis(trimethyl-ammoniudibromide
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  • nAChR,Decamethonium bromide,inhibit,Inhibitor,Decamethonium,Nicotinic acetylcholine receptors
  • Decamethonium Bromide, ≥ 98.0%
  • 541-22-0
  • C16H38N22Br
  • CH33NBrCH210NBrCH33
  • C16H38Br2N2
  • C16H38N2Br2
  • Br2C16H38N2
  • Analytical Chromatography Product Catalog
  • BioChemical
  • Ammonium Salts
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Ion Channels
  • Nicotinic Acetylcholine Receptor Modulators
  • Phase Transfer Catalysts
  • Synthetic Reagents
  • Quaternary Ammonium Compounds
  • Ammonium Bromides (Quaternary)
  • HPLC
  • Ligand-Gated Ion Channels
  • Ion Pair Reagents - Anionic
  • Ion Pair Reagents
  • IMPROMEN
  • Ammonium Bromides (Quaternary)
  • Quaternary Ammonium Compounds