ChemicalBook > CAS DataBase List > DECAMETHONIUM BROMIDE

DECAMETHONIUM BROMIDE

Product Name: DECAMETHONIUM BROMIDE
CAS No.: 541-22-0
Chemical Name: DECAMETHONIUM BROMIDE
Synonyms: decacuran;syncurine;dekamethoniumbromid;DECAMETHONIUM BROMIDE;decamethoniumdibromide;Decamethonium Bromide >Decamethonium bromide ,98%;Decamethonium Bromide, ≥ 98.0%;DECAMETHONIUM BROMIDE USP/EP/BP;Decamethonium bromide, 10 mM in DMSO
CBNumber: CB6360047
Molecular Formula: C16H38Br2N2
Formula Weight: 418.29
MOL File: 541-22-0.mol

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DECAMETHONIUM BROMIDE Property

Melting point:: 263-267 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
form: crystalline
color: off-white
Water Solubility: almost transparency
λmax: λ: 240 nm Amax: 0.04
λ: 250 nm Amax: 0.03
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02
Merck: 14,2847
BRN: 3728288
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 541-22-0(CAS DataBase Reference)
EPA Substance Registry System: Decamethonium dibromide (541-22-0)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: BP5950000
F: 3-10
HS Code: 2923.90.0100
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 oral in mouse: 190mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D1260
Product name: Decamethonium bromide
Purity: crystalline
Packaging: 5g
Price: $133
Updated: 2025/07/31

Sigma-Aldrich

Product number: D1260
Product name: Decamethonium bromide
Purity: crystalline
Packaging: 10g
Price: $246
Updated: 2025/07/31

TCI Chemical

Product number: D1314
Product name: Decamethonium Bromide
Purity: >98.0%(T)
Packaging: 5g
Price: $97
Updated: 2025/07/31

TCI Chemical

Product number: D1314
Product name: Decamethonium Bromide
Purity: >98.0%(T)
Packaging: 25g
Price: $292
Updated: 2025/07/31

Cayman Chemical

Product number: 24907
Product name: Decamethonium (bromide)
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

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DECAMETHONIUM BROMIDE Chemical Properties,Usage,Production

Description

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC₅₀ value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC₅₀ values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC₅₀ = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED₉₅ values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.

Chemical Properties

crystalline solid

Uses

antipsychotic

brand name

Syncurine (GlaxoSmithKline).

Biological Functions

Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.

General Description

Crystals derived from methanol and acetone.

Air & Water Reactions

Water soluble.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.

Fire Hazard

Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

References

[1] W. D. M. PATON Eleanor J Z. The action of d-tubocurarine and of decamethonium on respiratory and other muscles in the cat[J]. Journal of Physiology-London, 1951, 112 3-4: 311-331. DOI: 10.1113/jphysiol.1951.sp004531
[2] ROGER L PAPKE J A S Lynn Wecker. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 333 2: 501-518. DOI: 10.1124/jpet.109.164566
[3] J BREK EATON. Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.[J]. Molecular Pharmacology, 2003, 64 6: 1283-1294. DOI: 10.1124/mol.64.6.1283
[4] B ROBAIRE G K. Effects of edrophonium, eserine, decamethonium, d-tubocurarine, and gallamine on the kinetics of membrane-bound and solubilized eel acetylcholinesterase.[J]. Molecular Pharmacology, 1975, 11 6: 722-734.

DECAMETHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DECAMETHONIUM BROMIDE manufacturers

Dideu Industries Group Limited

Product: DECAMETHONIUM BROMIDE 541-22-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-07

Career Henan Chemical Co

Product: DECAMETHONIUM BROMIDE 541-22-0
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

541-22-0, DECAMETHONIUM BROMIDERelated Search:

TIN (II) BROMIDE Cerium(III) bromide hydrate Magnesium bromide hexahydrate TITANIUM(IV) BROMIDE NEODYMIUM(III) BROMIDE HYDRATE Erythromycin Bicalutamide Mifepristone Perindopril erbumine Gabapentin Azithromycin Manganese(II) bromide tetrahydrate Potassium bromide Sodium bromide Cesium bromide Lithium bromide MAGNESIUM BROMIDE DIETHYL ETHERATE Yttrium(III) bromide

1,10-Decanediaminium,N,N,N,N’,N’,N’-hexamethyl-,dibromide

10-decanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide

decacuran

decamethoniumdibromide

decamethylene-1,10-bistrimethylammoniumdibromide

decamethylenebis(trimethyl-ammoniudibromide

1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

dekamethoniumbromid

DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE)

DECAMETHONIUM BROMIDE

DECAMETHYLENEBIS[TRIMETHYL-AMMONIUM BROMIDE]

syncurine

DECAMETHONIUM BROMIDE, FOR ION PAIR CHRO MATOGRAPHY

1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, monobromide

Ammonium, decamethylenebis[trimethyl-, dibromide

Decamethonium bromide ,98%

N1,N1,N1,N10,N10,N10-hexaMethyldecane-1,10-diaMiniuM broMide

Decamethylene bis(trimethylammonium bromide), Decane-1,10-bis(trimethylammonium bromide)

Decamethonium Bromide &gt

DECAMETHONIUM BROMIDE USP/EP/BP

Decamethonium (Bromide)(Reagent for Ion-Pair Chromatography,99%)

nAChR,Decamethonium bromide,inhibit,Inhibitor,Decamethonium,Nicotinic acetylcholine receptors

Decamethonium Bromide, ≥ 98.0%

Decamethonium bromide, 10 mM in DMSO

541-22-0

C16H38N22Br

CH33NBrCH210NBrCH33

C16H38Br2N2

C16H38N2Br2

Br2C16H38N2

Analytical Chromatography Product Catalog

BioChemical

Ammonium Salts

Cell Biology

Cell Signaling and Neuroscience

Ion Channels

Nicotinic Acetylcholine Receptor Modulators

Phase Transfer Catalysts

Synthetic Reagents

Quaternary Ammonium Compounds

Ammonium Bromides (Quaternary)

HPLC

Ligand-Gated Ion Channels

Ion Pair Reagents - Anionic

Ion Pair Reagents

IMPROMEN

Ammonium Bromides (Quaternary)

Quaternary Ammonium Compounds