ChemicalBook > CAS DataBase List > Heptaethylene Glycol Monomethyl Ether
Heptaethylene Glycol Monomethyl Ether
- Product Name
- Heptaethylene Glycol Monomethyl Ether
- CAS No.
- 4437-01-8
- Chemical Name
- Heptaethylene Glycol Monomethyl Ether
- Synonyms
- 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol;mPEG7;MPEG7-OH;m-PEG7-alcohol;926630;MEO-PEG(7)-OH;HO-(CH2CH2O)7-Me;Methyl-PEG7-alcohol;MONOMETHOXY-PEG (N=7);METHOXYHEPTAETHYLENE GLYCOL
- CBNumber
- CB6362485
- Molecular Formula
- C15H32O8
- Formula Weight
- 340.41
- MOL File
- 4437-01-8.mol
More
Less
Heptaethylene Glycol Monomethyl Ether Property
- Boiling point:
- 150 °C(Press: 0.005 Torr)
- Density
- 1.09
- refractive index
- 1.4540-1.4580
- storage temp.
- -20°C
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3
- InChIKey
- AGWKUHGLWHMYTG-UHFFFAOYSA-N
- SMILES
- C(O)COCCOCCOCCOCCOCCOCCOC
- CAS DataBase Reference
- 4437-01-8(CAS DataBase Reference)
More
Less
Safety
- WGK Germany
- 3
- HS Code
- 29094990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 41749
- Product name
- O-Methyl-heptaethylene glycol
- Purity
- ≥95% (oligomer purity)
- Packaging
- 1G
- Price
- $130.2
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1046
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $108
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1046
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $373
- Updated
- 2025/07/31
Frontier Specialty Chemicals
- Product number
- JK441840
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- 97%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
AK Scientific
- Product number
- Y4948
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Packaging
- 5g
- Price
- $359
- Updated
- 2021/12/16
More
Less
Heptaethylene Glycol Monomethyl Ether Chemical Properties,Usage,Production
Description
m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
Definition
The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1].
reaction suitability
reagent type: cross-linking reagent
Synthesis
112-60-7
74654-05-0
4437-01-8
A 60% NaH dispersion in mineral oil was added in batches to a stirred solution of triacetylene glycol (35.7 mmol) in anhydrous DMF (25.7 mL) under nitrogen protection, and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (23.36 mmol) in anhydrous DMF (4 mL) was added in a single addition to the resulting salt, and stirring was continued for 3.5 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC with 12% unfolding agent ratio). Upon completion of the reaction, the reaction mixture was diluted with an equal volume of 1N HCl, extracted with ethyl acetate (2 x 20 mL) and the organic phase discarded. The aqueous phase was extracted and post-treated to give heptaglycol monomethyl ether in 82-84% yield.
IC 50
PEGs
References
[1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021).
Heptaethylene Glycol Monomethyl Ether Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Heptaethylene Glycol Monomethyl Ether Suppliers
- Tel
- 0519-82733646 13814799543
- sales_01@salutchem.com
- Country
- China
- ProdList
- 107
- Advantage
- 58
- Tel
- 025-58367986 17351780683
- Fax
- QQ3209878052
- amy.xiang@ally-chem.com
- Country
- China
- ProdList
- 354
- Advantage
- 60
- Tel
- 17721070236 15002190549;
- yanfen2023@126.com
- Country
- China
- ProdList
- 1837
- Advantage
- 58
- Tel
- 15114901355
- Fax
- 029-85310852
- 1002921772@qq.com
- Country
- China
- ProdList
- 190
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- 021-58955608,2250286 15921236618
- blinkzeng@gmail.com
- Country
- China
- ProdList
- 522
- Advantage
- 62
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7782
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 400-026-1533/(021) 6478-0600
- Fax
- +86 (21) 6459-2060
- sales@bokachem.com
- Country
- China
- ProdList
- 876
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-50426030 13856289449
- Fax
- 021-50426030
- 2630597085@qq.com
- Country
- China
- ProdList
- 1889
- Advantage
- 55
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 0431-0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 3936
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 027-65563561
- Fax
- 86-27-59218822
- sales@borenpharm.com
- Country
- China
- ProdList
- 1245
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 400-1166-196 15982826727
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 025-025-58367986 18913956109
- Fax
- QQ:3209878052
- amy.xiang@ally-chem.com
- Country
- China
- ProdList
- 568
- Advantage
- 58
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 1006
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19800
- Advantage
- 60
- Tel
- 021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 2998
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 8595
- Advantage
- 58
- Tel
- 021-16621358918; 18516310516
- Fax
- 13045646768
- zhenlipharma888@163.com
- Country
- China
- ProdList
- 19035
- Advantage
- 58
- Tel
- 571-86101219 18768477782
- Fax
- -
- sales09@leobiochem.com
- Country
- China
- ProdList
- 433
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 021-33555271 18201009191
- Fax
- 021-33555271
- MWen@9iLab.com
- Country
- China
- ProdList
- 133
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9717
- Advantage
- 58
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
- ProdList
- 4952
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 17753923223
- Fax
- 0539-6222546
- 2805221329@qq.com
- Country
- China
- ProdList
- 1474
- Advantage
- 58
More
Less
View Lastest Price from Heptaethylene Glycol Monomethyl Ether manufacturers
LAURENT
- Product
- mPEG7-OH 4437-01-8
- Price
- US $4788.00/kg
- Min. Order
- 0.5kg
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-15
XIAMEN SINOPEG BIOTECH CO., LTD.
- Product
- 2,5,8,11,14,17,20-heptaoxadocosan-22-ol 4437-01-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-10
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- HEPTAETHYLENE GLYCOL MONOMETHYL ETHER 4437-01-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
4437-01-8, Heptaethylene Glycol Monomethyl Ether Related Search:
1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane
mPEG6-CH2COOH
2,5,8,11,14,17,20-Heptaoxadocosane-22-thiol
m-PEG7-aldehyde
Polyethylene Glycol Monocetyl Ether
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER
NONAETHYLENE GLYCOL MONODODECYL ETHER
C10 E8
C14E8
Dicyclohexano-24-crown-8
C12E8
HEPTAETHYLENE GLYCOL MONODODECYL ETHER
POLY(ETHYLENE GLYCOL) (N) MONOMETHACRYLATE
Polyoxyethylene lauryl ether
C16 E8
Benzonatate
Polyoxyethylene stearate
HEPTAETHYLENE GLYCOL