ALX 5407 Hydrochloride

Product Name: ALX 5407 Hydrochloride
CAS No.: 200006-08-2
Chemical Name: ALX 5407 Hydrochloride
Synonyms: ALX 5407 HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE;(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride
CBNumber: CB6363477
Molecular Formula: C24H25ClFNO3
Formula Weight: 429.91
MOL File: Mol file

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ALX 5407 Hydrochloride Property

storage temp.: 2-8°C
solubility: DMSO: ~16 mg/mL, soluble
form: solid
color: off-white

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 22-24/25-61-60
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0897
Product name: ALX 5407 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $136
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0897
Product name: ALX 5407 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $429
Updated: 2025/07/31

Tocris

Product number: 1757
Product name: ALX 5407 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

TRC

Product number: A575815
Product name: ALX 5407 hydrochloride
Packaging: 1mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 285122
Product name: NFPS hydrochloride
Packaging: 5mg
Price: $420
Updated: 2021/12/16

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ALX 5407 Hydrochloride Chemical Properties,Usage,Production

Uses

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Uses

ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.

Biochem/physiol Actions

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

in vivo

ALX-5407 hydrochloride (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex^[1].

storage

Desiccate at +4°C

References

[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.

ALX 5407 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ALX 5407 Hydrochloride Suppliers

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200006-08-2, ALX 5407 HydrochlorideRelated Search:

SARCOSINE HYDROCHLORIDE

(+/-)-NFPS HYDROCHLORIDE

N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE

(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride

ALX 5407 HYDROCHLORIDE

200006-08-2

C24H24NO3FHCl

Amino Acids & Derivatives

Aromatics

Intermediates & Fine Chemicals

Neurochemicals

Pharmaceuticals

Amino Acids & Derivatives, Aromatics, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals