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2-BROMO-4-FLUORO-6-NITROTOLUENE

Product Name
2-BROMO-4-FLUORO-6-NITROTOLUENE
CAS No.
502496-33-5
Chemical Name
2-BROMO-4-FLUORO-6-NITROTOLUENE
Synonyms
1-bromo-5-fluoro-2-methyl-3-nitrobenzene;2-Bromo-4-fluoro-6-n;Bromo-4-fluoro-6-nit;Bromo-4-fluoro-6-nitrotoluene;2-BROMO-4-FLUORO-6-NITROTOLUENE;3-BroMo-5-fluoro-2-Methylnitrobenzene;Benzene, 1-broMo-5-fluoro-2-Methyl-3-nitro-;1-bromo-5-fluoro-2-methyl-3-nitrobenzene,2-Bromo-4-fluoro-6-nitrotoluene;3-Bromo-5-fluoro-2-methylnitrobenzene, 1-Bromo-5-fluoro-2-methyl-3-nitrobenzene
CBNumber
CB6368821
Molecular Formula
C7H5BrFNO2
Formula Weight
234.02
MOL File
502496-33-5.mol
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2-BROMO-4-FLUORO-6-NITROTOLUENE Property

Boiling point:
259.4±35.0 °C(Predicted)
Density 
1.696±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
fused chunks crystalline powder
color 
Faint lime fused chunks
InChI
InChI=1S/C7H5BrFNO2/c1-4-6(8)2-5(9)3-7(4)10(11)12/h2-3H,1H3
InChIKey
ZVDFTBJXUXQPAU-UHFFFAOYSA-N
SMILES
C1(Br)=CC(F)=CC([N+]([O-])=O)=C1C
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B692753
Product name
2-Bromo-4-fluoro-6-nitrotoluene
Packaging
1g
Price
$55
Updated
2021/12/16
TRC
Product number
B692753
Product name
2-Bromo-4-fluoro-6-nitrotoluene
Packaging
5g
Price
$125
Updated
2021/12/16
AK Scientific
Product number
J94964
Product name
2-Bromo-4-fluoro-6-nitrotoluene
Packaging
1g
Price
$15
Updated
2021/12/16
AK Scientific
Product number
J94964
Product name
2-Bromo-4-fluoro-6-nitrotoluene
Packaging
5g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
071184
Product name
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene
Purity
97%
Packaging
5g
Price
$54
Updated
2021/12/16
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2-BROMO-4-FLUORO-6-NITROTOLUENE Chemical Properties,Usage,Production

Uses

2-Bromo-4-fluoro-6-nitrotoluene is a pharmaceutical intermediate for the preparation of Remibrutinib. Remibrutinib is used for the treatment of chronic urticaria or urticaria and is currently in clinical development.

Synthesis

446-10-6

502496-33-5

Step 23a: 3-bromo-5-fluoro-2-methylaniline (Compound 0104-69) was added to a solution of trifluoroacetic acid (40 mL) containing 4-fluoro-2-nitrotoluene (10.0 g, 64.4 mmol). Subsequently, sulfuric acid (12.5 mL) was added slowly and N-bromosuccinimide (NBS, 17.2 g, 96.6 mmol) was added in batches. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was slowly poured into ice water and stirring was continued for 15 min. Extraction was carried out with ethyl acetate, the organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the target product 1-bromo-5-fluoro-2-methyl-3-nitrobenzene (15.0 g, 100% yield) as a yellow oil. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 2.41 (s, 3H), 7.96 (dd, J = 8.0,2.4Hz, 1H), 8.02 (dd, J = 8.0,2.4Hz, 1H).

References

[1] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 155
[2] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0279; 0280
[3] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0252
[4] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 66
[5] Patent: WO2008/152387, 2008, A1. Location in patent: Page/Page column 33

2-BROMO-4-FLUORO-6-NITROTOLUENE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-FLUORO-6-NITROTOLUENE Suppliers

China 164 France 1 Germany 1 India 4 United Kingdom 3 United States 12 Global 185
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 2-BROMO-4-FLUORO-6-NITROTOLUENE manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
2-Bromo-4-fluoro-6-nitrotoluene 502496-33-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞98% by HPLC
Supply Ability
200kg/month
Release date
2025-11-12
Career Henan Chemical Co
Product
2-BROMO-4-FLUORO-6-NITROTOLUENE 502496-33-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

502496-33-5, 2-BROMO-4-FLUORO-6-NITROTOLUENERelated Search:


  • 2-Bromo-4-fluoro-6-n
  • 2-BROMO-4-FLUORO-6-NITROTOLUENE
  • 1-bromo-5-fluoro-2-methyl-3-nitrobenzene
  • 3-Bromo-5-fluoro-2-methylnitrobenzene, 1-Bromo-5-fluoro-2-methyl-3-nitrobenzene
  • Benzene, 1-broMo-5-fluoro-2-Methyl-3-nitro-
  • 3-BroMo-5-fluoro-2-Methylnitrobenzene
  • Bromo-4-fluoro-6-nitrotoluene
  • Bromo-4-fluoro-6-nit
  • 1-bromo-5-fluoro-2-methyl-3-nitrobenzene,2-Bromo-4-fluoro-6-nitrotoluene
  • 502496-33-5
  • Halogen toluene
  • Intermediate