BENZIMIDAVIR

Product Name: BENZIMIDAVIR
CAS No.: 176161-24-3
Chemical Name: BENZIMIDAVIR
Synonyms: Maribavir;1263W94;Maribavi;Malibawei;Malibave.;BW 1263W94;GW 257406X;BENZIMIDAVIR;Maribavir Impurity Crystal-Free Type VI;5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
CBNumber: CB6375292
Molecular Formula: C15H19Cl2N3O4
Formula Weight: 376.24
MOL File: 176161-24-3.mol

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BENZIMIDAVIR Property

Boiling point:: 611.0±65.0 °C(Predicted)
Density: 1.67±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO
form: Powder
pka: 13.20±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2941
Product name: Maribavir
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2941
Product name: Maribavir
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $476
Updated: 2024/03/01

ApexBio Technology

Product number: B3517
Product name: Maribavir
Packaging: 10mg
Price: $551
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004838
Product name: MARIBAVIR
Purity: 95.00%
Packaging: 5MG
Price: $660
Updated: 2021/12/16

ApexBio Technology

Product number: B3517
Product name: Maribavir
Packaging: 5mg
Price: $347
Updated: 2021/12/16

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BENZIMIDAVIR Chemical Properties,Usage,Production

Description

Maribavir is an orally bioavailable benzimidazole L-riboside antiviral, with a spectrum of activity essentially limited to human cytomegalovirus (CMV) and Epstein–Barr virus (EBV). It is an inhibitor of the CMV UL97 kinase. As of 2008, maribavir was in phase III clinical trials for prevention of CMV infection in transplant recipients at risk. Earlier phase I and II trials of maribavir showed anti-CMV activity with an acceptable adverse effect profile. Investigational drug code names include 1263W94, BW1263-W94, GW257406X, and VP41263, reflecting changes in ownership during drug development. As of early 2009, the drug was being developed under ‘‘fast track’’ status granted by the US Food and Drug Administration, but the apparent failure of maribar prophylaxis to prevent CMV infection in stem cell transplant recipients in the definitive phase III clinical trial resulted in the sponsor halting ongoing clinical development.

Uses

Treatment of cytomegalovirus infections (antiviral).

Mechanism of action

Maribavir inhibits the CMV UL97 kinase, an enzyme which is required for the normal replication of the virus . In the absence of functioning UL97 kinase, viral replication is severely impaired in vitro, with an abnormal cell culture cytopathic effect characterized by the nuclear aggregation of excess amorphous viral proteins, mainly the tegument protein pp65. Impaired UL97 function appears to cause a defect in viral encapsidation and/or egress of viral particles from the nucleus. In addition, viral DNA synthesis may also be reduced. CMV replication is not completely shut off in the absence of the UL97 kinase; the widely varying maribavir IC50s under different assay conditions suggest that host cells can variably substitute for the normal function of UL97, a factor that may affect the therapeutic potency of maribavir in vivo.

Drug interactions

Since CYP3A4 appears to be the major maribavir-metabolizing enzyme, there are potential drug interactions with CYP3A4 inhibitors, such as azole antifungals, macrolide antibiotics, and HIV protease inhibitors, or CYP3A4 inducers, such as rifampicin or efavirenz. There are insufficient data to assess the clinical significance of this interaction. Phase I clinical trials examined the pharmacokinetics of maribavir in HIV-infected subjects, many of whom were concomitantly using antifungals and protease inhibitors. Overall, the pharmacokinetic data were not significantly different from those of healthy individuals not on these drugs. In healthy adults, oral administration of ketoconazole, a potent CYP3A4 inhibitor, resulted in a 35% decrease in the clearance of maribavir, which is not expected to have adverse consequences because of the low observed toxicity of maribavir. Further studies are required to assess potential impairment of antiviral activity by CYP3A4 inducers. Maribavir may have some inhibitory effect on cytochrome P450 isozymes, CYP2C19 and CYP2D6, as assessed after administration of multiple concurrently administered drug probes, including omeprazole (2C19) and dextromethorphan (2D6).

BENZIMIDAVIR Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZIMIDAVIR Suppliers

China 137 Germany 1 India 1 United Kingdom 2 United States 16 Global 157

LGM Pharma

Tel: 1-(800)-881-8210
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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Advantage: 58

Alchem Pharmtech,Inc.

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Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

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Email: info@protheragen-ing.com
Country: United States
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ApexBio Technology

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Country: United States
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MedChemExpress

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Matrix Scientific

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AlliChem, LLC

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2A PharmaChem USA

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3B Scientific Corporation

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APAC Pharmaceutical, LLC

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ChemPacific Corporation

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BOSCHE SCIENTIFIC, LLC

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176161-24-3, BENZIMIDAVIRRelated Search:

N,N-DIETHYLBENZAMIDE 1-PROPYL-1H-BENZOIMIDAZOL-2-YLAMINE 6-CHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE 1-HYDROXYMETHYLBENZIMIDAZOLE 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI) 5,6-DICHLORO-2-ISOPROPYLAMINOBENZIMIDAZOLE 1,4-ANHYDRO-L-RIBITOL 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE BENZIMIDAVIR

Maribavi

5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

BENZIMIDAVIR

BENZIMIDAVIR, 5,6-DICHLORO-2-（ISOPROPYLAMINO）-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE

5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE

BENZIMIDAVIR: 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(SS-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE

(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetr

Maribavir

1263W94

5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine

BW 1263W94

GW 257406X

(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)t

1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-

Malibawei

Malibave.

Maribavir Impurity Crystal-Free Type VI

176161-24-3

76161-24-3

C15H19Cl2N3O4

Inhibitors