2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

Product Name: 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
CAS No.: 642008-81-9
Chemical Name: 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Synonyms: BRD6989;BRD6989 (BRD-6989;BRD6989 >=98% (HPLC);BRD6989, 10 mM in DMSO;2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile;2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile;CDK8,BRD 6989,Inhibitor,inhibit,CDK19,IL-10,inflammatory,BRD6989,Cyclin dependent kinase,BRD-6989,BMDCs,Interleukin Related,cortistatin-A,CDK
CBNumber: CB63760967
Molecular Formula: C16H16N4
Formula Weight: 264.33
MOL File: 642008-81-9.mol

More

Less

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Property

storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
color: white to beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2208
Product name: BRD6989
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2208
Product name: BRD6989
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $329
Updated: 2024/03/01

Tocris

Product number: 6438
Product name: BRD6989
Purity: ≥98%(HPLC)
Packaging: 10
Price: $133
Updated: 2021/12/16

Tocris

Product number: 6438
Product name: BRD6989
Purity: ≥98%(HPLC)
Packaging: 50
Price: $562
Updated: 2021/12/16

TRC

Product number: B677688
Product name: BRD6989
Packaging: 5mg
Price: $250
Updated: 2021/12/16

More

Less

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Chemical Properties,Usage,Production

Uses

BRD 6989, is a small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells.

Definition

ChEBI: 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines.

Biological Activity

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) th at upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μM, respectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM.

storage

Store at +4°C

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Suppliers

China 31 Finland 1 Russia 1 United Kingdom 2 United States 8 Global 43

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 6021
Advantage: 55

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4348
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10524
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4988
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62072
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24641
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9988
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2986
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 4997
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 1316706386
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48458
Advantage: 58

Shanghai Hansi Chemical Industry Co., Ltd.

Tel: 17717618050
Email: zllg@gh-reagent.com
Country: China
ProdList: 10422
Advantage: 58

Hunan Hui Bai Yi New Materials Co., Ltd

Tel: 0745-2866551 19374576088
Email: 571960571@qq.com
Country: China
ProdList: 7138
Advantage: 58

R&D Systems, Inc

Tel: 18003437475 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 35960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 47255
Advantage: 58

Cayman Chemical Company

Tel: 800-3649897
Email: Caymanname@qq.com
Country: China
ProdList: 21643
Advantage: 58

Merck KGaA

Tel: (+86) 21 2033 8288
Email: sigmaname@qq.com
Country: CHINA
ProdList: 292394
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6591
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6213
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

642008-81-9, 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrileRelated Search:

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

BRD6989 (BRD-6989

2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

BRD6989

BRD6989 >=98% (HPLC)

CDK8,BRD 6989,Inhibitor,inhibit,CDK19,IL-10,inflammatory,BRD6989,Cyclin dependent kinase,BRD-6989,BMDCs,Interleukin Related,cortistatin-A,CDK

BRD6989, 10 mM in DMSO

642008-81-9