ChemicalBook > CAS DataBase List > MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2

MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2

Product Name: MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2
CAS No.: 192723-42-5
Chemical Name: MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2
Synonyms: TACE substrate;MCA-PLAQAV(DPA)RSSSR-NH2;MCA-PLAQAVDAP(DNP)RSSSR-NH2;Mca-PLAQAVDap(Dnp)RSSRSR-NH2;TACE SUBSTRATE II, FLUOROGENIC;FLUORESCENT PEPTIDE SUBSTRATE III;ADAM-17 SUBSTRATE II, FLUOROGENIC;Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide;TNF-ALPHA CONVERTASE ENZYME SUBSTRATE, FLUOROGENIC;Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (hum
CBNumber: CB6377155
Molecular Formula: C69H103N23O24
Formula Weight: 1638.7
MOL File: 192723-42-5.mol

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MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: -15°C
pka: 12.49±0.46(Predicted)
Sequence: {Mca}-Pro-Leu-Ala-Gln-Ala-Val-{Dpa}-Arg-Ser-Ser-Ser-Arg-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Chem-Impex

Product number: 33017
Product name: Mca-(endo-1a-Dap(Dnp))-TNF-α(-5to+6)amide(human)trifluoroacetatesalt
Packaging: 1MG
Price: $232.96
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002462
Product name: MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2
Purity: 95.00%
Packaging: 5MG
Price: $500.09
Updated: 2021/12/16

Chem-Impex

Product number: 33017
Product name: Mca-(endo-1a-Dap(Dnp))-TNF-α(-5to+6)amide(human)trifluoroacetatesalt
Packaging: 5MG
Price: $933
Updated: 2021/12/16

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MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 Chemical Properties,Usage,Production

Uses

Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis[1].

IC 50

ADAM10; ADAM17

References

[1] Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017.
[2] Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5. DOI:10.1016/j.antiviral.2009.12.001
[3] Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6. DOI:10.1038/jid.2011.462
[4] Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32.

MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 Suppliers

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192723-42-5, MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2Related Search:

PSW 2 FULL VERSION

ADAM-17 SUBSTRATE II, FLUOROGENIC

MCA-(ENDO-1A-DAP(DNP))-TNF-A (-5 TO +6) AMIDE (HUMAN)

MCA-(ENDO-1A-DAP(DNP))-TNF-ALPHA (-5 TO +6) AMIDE (HUMAN)

MCA-(ENDO-1A-DAP(DNP))-TUMOR NECROSIS FACTOR-ALPHA (-5 TO +6) AMIDE (HUMAN)

MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2

MCA-PRO-LEU-ALA-GLN-ALA-VAL-DPA-ARG-SER-SER-SER-ARG-NH2

MCA-PLAQAVDAP(DNP)RSSSR-NH2

MCA-PLAQAV(DPA)RSSSR-NH2

FLUORESCENT PEPTIDE SUBSTRATE III

TACE SUBSTRATE II, FLUOROGENIC

TNF-ALPHA CONVERTASE ENZYME SUBSTRATE, FLUOROGENIC

Mca-PLAQAVDap(Dnp)RSSRSR-NH2

L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl- (9CI)

L-Argininamide,1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-

MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 USP/EP/BP

Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human) trifluoroacetate salt

Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide

Mca-(endo-1a-Dap (Dnp))-TNF-a (-5 to +6) amide (human) trifluoroacetate salt

TACE substrate

Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (hum

192723-42-5

C69H103N23O24

peptide