ChemicalBook > CAS DataBase List > Cefotiam hydrochloride

Cefotiam hydrochloride

Product Name
Cefotiam hydrochloride
CAS No.
66309-69-1
Chemical Name
Cefotiam hydrochloride
Synonyms
CEFOTIAM 2HCL;Spizef;Ceftiam;Halospor;Sporidyn;Pansporin;Cefapicol;Pansporine;Kemisporin;Sepidnarin
CBNumber
CB6386641
Molecular Formula
C18H23N9O4S3.HCl
Formula Weight
562.08
MOL File
66309-69-1.mol
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Cefotiam hydrochloride Property

Melting point:
>93°C (dec.)
Boiling point:
94℃
RTECS 
XI0367000
Flash point:
>110°(230°F)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: ≥22M
form 
powder
color 
white to tan
Water Solubility 
Soluble in water
Stability:
Hygroscopic
InChIKey
BWRRTAXZCKVRON-DGPOFWGLSA-N
CAS DataBase Reference
66309-69-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2941906000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0056
Product name
Cefotiam dihydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
10mg
Price
$34.4
Updated
2024/03/01
Alfa Aesar
Product number
J66529
Product name
Cefotiam dihydrochloride
Packaging
100mg
Price
$403
Updated
2024/03/01
Alfa Aesar
Product number
J66529
Product name
Cefotiam dihydrochloride
Packaging
50mg
Price
$262
Updated
2023/06/20
Sigma-Aldrich
Product number
SML0056
Product name
Cefotiam dihydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
50mg
Price
$268
Updated
2024/03/01
TRC
Product number
C243005
Product name
Cefotiam dihydrochloride
Packaging
500mg
Price
$520
Updated
2021/12/16
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Cefotiam hydrochloride Chemical Properties,Usage,Production

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Uses

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefotiam hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefotiam hydrochloride Suppliers

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View Lastest Price from Cefotiam hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cefotiam hydrochloride 66309-69-1
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
81%min
Supply Ability
500kg
Release date
2021-08-17
Hebei Henghe Import and Export Trading Co. LTD
Product
cefotiam hydrochloride 66309-69-1
Price
US $220.00/KG
Min. Order
10KG
Purity
99%
Supply Ability
10
Release date
2020-12-09
Hebei Henghe Import and Export Trading Co. LTD
Product
cefotiam hydrochloride 66309-69-1
Price
US $250.00/IU
Min. Order
500KG
Purity
99%
Supply Ability
5
Release date
2020-11-24

66309-69-1, Cefotiam hydrochlorideRelated Search:

Metoclopramide hydrochloride Cefazedone sodium salt Cefonicid sodium Cemandil sodium salt Cefotaxime sodium Ceftezole sodium Cefcapene pivoxil hydrochloride Bromhexine hydrochloride Ceftiofur hydrochloride Oxytetracycline hydrochloride Cefozopran hydrochloride Cefetamet pivoxil hydrochloride Cefmenoxime hydrochloride Nitrocefin Ceftazidime 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol 2-Aminothiazole-4-acetic acid Oxygen

  • cefotiam hydrochloride
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
  • Abbott 48999
  • Halospor
  • Pansporin
  • Pansporine
  • Spizef
  • Sporidyn
  • Cefotiam Hydrochloride (350 mg)
  • (6R,7R)-7-[2-(2-aMino-1,3-thiazol-4-yl)acetaMido]-3-[({1-[2-(diMethylaMino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6r-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
  • Cefapicol
  • Kemisporin
  • Sepidnarin
  • (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • (6R,7R)-7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)tetrazol-5-yl]thio]methyl]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • (6R,7R)-7-[2-(2-azanyl-1,3-thiazol-4-yl)ethanoylamino]-3-[[1-(2-dimethylaminoethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • Cefotiam Hydrochloride (325 mg)
  • cefotiamdihydrochloride
  • dihydrochloride,(6r-trans)--oxo
  • CEFOTIAM 2HCL
  • (6R,7R)-7-[[2-(2-AMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride
  • 20MG/100MG/KG
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-,hydrochloride (1:2), (6R,7R)-
  • Ceftiam
  • (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate
  • Cefotiam dihydrochloride hydrate
  • cefotian Hydrochloride
  • Cefotiam DiHCl
  • 7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
  • Cefotiam Dihydrochloride(Crude)
  • SCE-963 hydrochloride
  • (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • Cefotiam hydrochloride USP/EP/BP
  • (6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid
  • Cefotiam hydrochloride Impurities
  • Cefotiam Hydrochloride (1098005)
  • Cefotiame hydrochloride
  • 66309-69-1
  • 6309-69-1
  • 66309-69-01
  • C18H23N9O4S3
  • C18H23N9O4S3HCl
  • C18H23N9O4S32HCl
  • C18H24ClN9O4S3
  • C18H25Cl2N9O4S3
  • 59855
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