(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride

Product Name: (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride
CAS No.: 1217741-83-7
Chemical Name: (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride
Synonyms: 2H3]-Sertraline HCI;Sertraline hydrochloride salt;[2H3]- Sertraline Hydrochloride;(±)-cis-Sertraline-d3 Hydrochloride;rac-cis-Sertraline-d3 Hydrochloride;(±)-cis-Sertraline-d3 HCl (N-methyl-d3);(±)-cis-Sertraline-d3 hydrochloride (N-methyl-d3);(±)-cis-Sertraline-d3 hydrochloride (N-methyl-d3) in methanol;(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride;Sertraline-d3 HydrochlorideQ: What is Sertraline-d3 Hydrochloride Q: What is the CAS Number of Sertraline-d3 Hydrochloride
CBNumber: CB63883206
Molecular Formula: C17H15Cl3D3N
Formula Weight: 345.709005334
MOL File: 1217741-83-7.mol

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(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride Property

storage temp.: -20°C
solubility: Methanol: soluble
form: A solid
Stability:: Store in Freezer, Store In Freezer

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: S280002
Product name: Sertraline-d3Hydrochloride
Packaging: 10mg
Price: $1210
Updated: 2021/12/16

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(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride Chemical Properties,Usage,Production

Uses

The isotopically labelled version of Sertraline, a selective serotonin reuptake inhibitor. Used as an antidepressant.

Biological Activity

Sertraline-d3 is intended for use as an internal standard for the quantification of sertraline by GC- or LC-MS. Sertraline is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits monoamine uptake by the serotonin transporter (SERT) with an IC50 value of 70 nM.1 It is selective for SERT over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively). Sertraline (3.2-56 mg/kg, s.c.) reduces immobility in the forced swim test in mice.2 Sertraline (5 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide.3 Formulations containing sertraline have been used in the treatment of depression, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and various anxiety disorders.

References

1.Welch, W.M., Kraska, A.R., Sarges, R., et al.Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralinsJ. Med. Chem.27(11)1508-1515(1984) 2.Koe, B.K., Weissman, A., Welch, W.M., et al.Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotoninJ. Pharmacol. Exp. Ther.226(3)686-700(1983) 3.Carpinteiro, A., Edwards, M.J., Hoffmann, M., et al.Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cellsCell Rep. Med.1(8)100142(2020)

(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride Suppliers

Canada 1 China 17 India 3 United States 1 Global 22

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1217741-83-7, (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochlorideRelated Search:

1(2H)-Naphthalenone,3,4-dihydro-4-phenyl- rac 4-(2,3-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone Sertraline Impurity 20 Sertraline Impurity 23 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenimine Rac-trans-Sertraline Sertraline hydrochloride Sertraline Sertraline Impurity 22 Sertraline-RC 11 Impurity (1R,4R)-Sertraline 4-Chlorophenyl IMpurity HCl 4-(4-Chlorophenyl)-3,4-dihydro-1(2H)-naphthalenone 3-Dechloro Sertraline Hydrochloride Sertraline Carbamoyl Glucuronide (1R,4S) Sertraline Hydrochloride Sertraline Impurity 21 4-(3,4-Dichlorophenyl)-1-tetralone 1(2H)-Naphthalenone, 4-(3-chlorophenyl)-3,4-dihydro-

(1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride

[2H3]- Sertraline Hydrochloride

(±)-cis-Sertraline-d3 hydrochloride (N-methyl-d3)

(±)-cis-Sertraline-d3 HCl (N-methyl-d3)

Sertraline hydrochloride salt

Sertraline-d3 HydrochlorideQ: What is Sertraline-d3 Hydrochloride Q: What is the CAS Number of Sertraline-d3 Hydrochloride

2H3]-Sertraline HCI

rac-cis-Sertraline-d3 Hydrochloride

(±)-cis-Sertraline-d3 Hydrochloride

(±)-cis-Sertraline-d3 hydrochloride (N-methyl-d3) in methanol

1217741-83-7