4-(Boc-aminomethyl)aniline
- Product Name
- 4-(Boc-aminomethyl)aniline
- CAS No.
- 94838-55-8
- Chemical Name
- 4-(Boc-aminomethyl)aniline
- Synonyms
- 4-[(N-Boc)aminomethyL;4-(BOC-AMINOMETHYL)-ANILINE;4-(N-boc-aminomethyl)anline;4-(N-BOC-AMINOMETHYL)ANILINE;4-[(N-tert-Butyloxycarbonyl)aMi;4-[(N-Boc)aMinoMethyl]aniline 97%;TERT-BUTYL (4-AMINOBENZYL)CARBAMATE;4-[(N-Boc)aminomethyl]aniline;(4-aminobenzyl)(tert-butyl)carbamate;TERT-BUTYL N-(4-AMINOBENZYL)CARBAMATE
- CBNumber
- CB6395849
- Molecular Formula
- C12H18N2O2
- Formula Weight
- 222.28
- MOL File
- 94838-55-8.mol
4-(Boc-aminomethyl)aniline Property
- Melting point:
- 75-78 °C(lit.)
- Boiling point:
- 382.3±25.0 °C(Predicted)
- Density
- 1.095±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 12.62±0.46(Predicted)
- form
- Crystalline Powder
- color
- White to tan
- InChI
- InChI=1S/C12H18N2O2/c1-12(2,3)16-11(15)14-8-9-4-6-10(13)7-5-9/h4-7H,8,13H2,1-3H3,(H,14,15)
- InChIKey
- UXWQXBSQQHAGMG-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCC1=CC=C(N)C=C1
- CAS DataBase Reference
- 94838-55-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 525626
- Product name
- 4-[(N-Boc)aminomethyl]aniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $65.83
- Updated
- 2025/07/31
- Product number
- B619800
- Product name
- 4-(N-Boc-aminomethyl)aniline
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CHM0024763
- Product name
- 4-(N-BOC-AMINOMETHYL)ANILINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $172.2
- Updated
- 2021/12/16
- Product number
- FB18927
- Product name
- 4-(N-Boc-aminomethyl)aniline
- Packaging
- 10g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 046294
- Product name
- tert-Butyl N-(4-aminobenzyl)carbamate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $244
- Updated
- 2021/12/16
4-(Boc-aminomethyl)aniline Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4-[(N-Boc)aminomethyl]aniline may be used in the synthesis of haptens and 4-(N-boc-aminomethyl)benzene diazonium tetrafluoroborate salt.
Uses
An aniline derivative, 4-(Boc-aminomethyl)aniline can be used in the preparation of various organic synthase inhibitors and other bio-active compounds.
General Description
4-[(N-Boc)aminomethyl]aniline is a protected amine.
Synthesis
94838-58-1
94838-55-8
General procedure for the synthesis of 4-(N-BOC-aminomethyl)aniline from N-Boc-4-nitrophenylethylamine: 10% Pd/C catalyst (62 mg) was added to a solution of N-Boc-4-nitrophenylethylamine (590 mg, 2.33 mmol) in methanol (20.6 mL). The reaction mixture was subjected to hydrogenation under 35 psi hydrogen pressure for 2 hours at room temperature. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was evaporated. The residue was purified by silica gel column chromatography using ethyl acetate with hexane (1:1) as eluent to afford 4-(N-BOC-aminomethyl)aniline (520 mg, 100% yield) as an oil.1H NMR (DMSO-d6): δ 1.37 (s, 9H), 3.91 (d, J=6.0 Hz, 2H), 4.90 (s, 2H disappeared after D2O exchange), 6.47 (d, J=8.1Hz, 2H), 6.87 (d, J=8.0Hz, 2H), 7.13ppm (s, 1H, disappeared after D2O exchange).IR: ν1695, 2974 cm-1.
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 101 - 111
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 5, p. 691 - 701
[3] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 48
[4] Chemical Communications, 2014, vol. 50, # 97, p. 15305 - 15308
[5] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 6, p. 553 - 557
4-(Boc-aminomethyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Boc-aminomethyl)aniline manufacturers
- Product
- 4-(N-Boc-Aminomethyl)aniline 94838-55-8
- Price
- US $800.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-03-06
- Product
- 4-(N-BOC-AMINOMETHYL)ANILINE 94838-55-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-09