1,2,3-BENZOTHIADIAZOLE
- Product Name
- 1,2,3-BENZOTHIADIAZOLE
- CAS No.
- 273-77-8
- Chemical Name
- 1,2,3-BENZOTHIADIAZOLE
- Synonyms
- benzo[d][1,2,3]thiadiazole;AKOS 90367;1,2,3-BENZOTHIADIAZOLE;BENZO[1,2,3]THIADIAZOLE;Perospirone Impurity 32(Octhilinone)
- CBNumber
- CB6395854
- Molecular Formula
- C6H4N2S
- Formula Weight
- 136.17
- MOL File
- 273-77-8.mol
1,2,3-BENZOTHIADIAZOLE Property
- Melting point:
- 295 °C (decomp)
- Boiling point:
- 220.5±23.0 °C(Predicted)
- Density
- 1.368±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -2.83±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H260In contact with water releases flammable gases which may ignite spontaneously
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
H351Suspected of causing cancer
H371May cause damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P231+P232Handle under inert gas. Protect from moisture.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P335+P334Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P402+P404Store in a dry place. Store in a closed container.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B130870
- Product name
- 1,2,3-Benzothiadiazole
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 3982CA
- Product name
- 1,2,3-Benzothiadiazole
- Packaging
- 250mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 176209
- Product name
- 1,2,3-Benzothiadiazole
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- 176209
- Product name
- 1,2,3-Benzothiadiazole
- Packaging
- 5g
- Price
- $1206
- Updated
- 2021/12/16
- Product number
- 176209
- Product name
- 1,2,3-Benzothiadiazole
- Packaging
- 10g
- Price
- $1602
- Updated
- 2021/12/16
1,2,3-BENZOTHIADIAZOLE Chemical Properties,Usage,Production
Synthesis
137-07-5
273-77-8
The general procedure for the synthesis of benzo[d][1,2,3]thiadiazole from 2-aminothiophenol was as follows: o-aminothiophenol (0.3 mmol, 1 eq.) and tert-butyl nitrite (0.45 mmol, 1.5 eq.) were sequentially added to the reaction vessel at room temperature (25 °C), followed by the addition of 2 mL of water as reaction solvent. The reaction mixture was stirred at 25 °C for 3 min. After the reaction was completed, 10 mL of ethyl acetate was added to dilute the reaction solution, and the diluted solution was transferred to a partition funnel and extracted with saturated saline to separate the aqueous and organic phases. The aqueous phase was then extracted with ethyl acetate 2 to 4 times. All organic phases were combined and dried with 5 g of anhydrous sodium sulfate for 5 min, followed by filtration. The filter cake was washed with ethyl acetate (5 mL x 3 times) and then concentrated under reduced pressure. Finally, the concentrate was separated by column chromatography (eluent was petroleum ether to ethyl acetate 3:1 by volume) and the eluate was collected. After removing the solvent, a white liquid product was obtained in 96% yield.
Purification Methods
1,2,3-Benzothiadiazole crystallises from pet ether, and has at 264 and 306nm in hexane. [Overberger et al. J Org max Soc 24 1407 1959, Beilstein 27 III/IV 7113.]
References
[1] Synthesis, 2011, # 13, p. 2154 - 2158
[2] Patent: CN107311960, 2017, A. Location in patent: Paragraph 0044-0047; 0144-0147
[3] Patent: WO2011/100502, 2011, A1. Location in patent: Page/Page column 48-49
[4] Phosphorus and Sulfur and the Related Elements, 1984, vol. 19, p. 279 - 284
[5] Justus Liebigs Annalen der Chemie, 1893, vol. 277, p. 227,228
1,2,3-BENZOTHIADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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