ChemicalBook > CAS DataBase List > FMOC-L-CYCLOPROPYLGLYCINE

FMOC-L-CYCLOPROPYLGLYCINE

Product Name
FMOC-L-CYCLOPROPYLGLYCINE
CAS No.
1212257-18-5
Chemical Name
FMOC-L-CYCLOPROPYLGLYCINE
Synonyms
Fmoc-L-Gly(cPr)-OH;Fmoc-L-Cyclopropylgly;Fmoc-CyclopropylGly-OH;FMOC-L-CYCLOPROPYLGLYCINE;(S)-Fmoc-cyclopropylglycine;N-Fmoc-S-2-Cyclopropylglycine;Fmoc-(S)-2-cyclopropylglycine;FMOC-L-CYCLOPROPYLGLYCINE ,98% min;Fmoc-(S)-Amino-cyclopropyl-acetic acid;Fmoc-L-cyclopropylglycine≥ 99% (HPLC, Chiral purity)
CBNumber
CB6409672
Molecular Formula
C20H19NO4
Formula Weight
337.37
MOL File
Mol file
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FMOC-L-CYCLOPROPYLGLYCINE Property

Boiling point:
577.1±33.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.85±0.10(Predicted)
form 
powder
color 
White
optical activity
17.134°(C=0.01g/ml DCM)
InChI
InChI=1S/C20H19NO4/c22-19(23)18(12-9-10-12)21-20(24)25-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18H,9-11H2,(H,21,24)(H,22,23)/t18-/m0/s1
InChIKey
YMLZBPTXRMNAFP-SFHVURJKSA-N
SMILES
C1(COC(=O)N[C@H](C(O)=O)C2CC2)C2C=CC=CC=2C2C=CC=CC=21
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Safety

Hazard Codes 
Xi
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
F657745
Product name
Fmoc-L-cyclopropylglycine
Packaging
500mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
277693
Product name
Fmoc-L-cyclopropylglycine
Packaging
50mg
Price
$333
Updated
2021/12/16
TRC
Product number
F657745
Product name
Fmoc-L-cyclopropylglycine
Packaging
5g
Price
$460
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-1-T6
Product name
L-Cyclopropylglycine, N-Fmoc protected
Packaging
1g
Price
$477
Updated
2021/12/16
Apolloscientific
Product number
OR2679
Product name
(S)-Amino(cyclopropyl)acetic acid, N-FMOC protected
Packaging
1g
Price
$403
Updated
2021/12/16
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FMOC-L-CYCLOPROPYLGLYCINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Fmoc-L-cyclopropylglycine is used in preparation of tailored Cyclodepsipeptides as potent non-covalent serine protease inhibitors.

Synthesis

28920-43-6

49606-99-7

1212257-18-5

GENERAL STEPS: 2.3 g of Na2CO3 was dissolved in 34 mL of water and chloroformic acid-9-fluorenylmethyl ester and (S)-2-amino-2-cyclopropylacetic acid were added with stirring. The reaction mixture was stirred at room temperature. After completion of the reaction, the product was characterized by FT-IR and NMR.FT-IR (pure): 2669, 2335, 2159, 2106, 1785, 1689, 1550, 1489, 1463, 1433, 1369, 1296, 1253, 1172, 1128, 1001 cm^-1.^1H NMR ( CDCl3, 600 MHz): δ = 7.76 (d, 2H, J = 7.2 Hz), 7.60-7.59 (m, 2H), 7.41-7.39 (m, 2H), 7.32-7.30 (m, 2H), 5.36 (d, 1H, J = 6 Hz), 4.45-4.39 (m, 2H), 4.24-4.21 (m, 1H ), 3.83-3.81 (m, 1H), 1.14-1.13 (m, 1H), 0.65-0.46 (m, 5H) ppm. ^13C NMR (CDCl3, 150 MHz): δ = 176.6, 156.2, 143.9, 143.8, 141.4, 127.9, 127.2, 125.2, 125.1 , 120.1, 67.3, 57.4, 47.3, 13.9, 3.4 ppm. HRMS (ESI): m/z [M + Na]^+ Calculated value C20H19NO4Na 360.1206, measured value 360.1193.

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 5, p. 1698 - 1708
[2] Patent: WO2016/138288, 2016, A1. Location in patent: Page/Page column 124

FMOC-L-CYCLOPROPYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-L-CYCLOPROPYLGLYCINE Suppliers

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1212257-18-5, FMOC-L-CYCLOPROPYLGLYCINERelated Search:

FMOC-ALA(BETA-CYCLOBUTYL)-OH FMOC-L-CYCLOPROPYLALANINE FMOC-L-CYCLOPENTYLGLYCINE Fmoc-cyclopropylglycine FMOC-D-CYCLOPROPYLGLYCINE L-Cyclopropylglycine

  • FMOC-L-CYCLOPROPYLGLYCINE
  • L-2-Cyclopropylglycine, N-FMOC protected, (S)-Cyclopropyl({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
  • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic acid
  • (2S)-2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
  • (S)-Fmoc-cyclopropylglycine
  • (alphaS)-alpha-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopropaneacetic acid
  • Fmoc-(S)-Amino-cyclopropyl-acetic acid
  • Fmoc-L-cyclopropylglycine≥ 99% (HPLC, Chiral purity)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Cyclopropylglycine (EE >98%)
  • N-Fmoc-S-2-Cyclopropylglycine
  • Cyclopropaneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αS)-
  • Fmoc-(S)-2-cyclopropylglycine
  • N-α-(9-Fluorenylmethoxycarbonyl)-L-α-cyclopropylglycine
  • Fmoc-L-Cyclopropylgly
  • (2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)aceticaci
  • Fmoc-L-Gly(cPr)-OH
  • FMOC-L-CYCLOPROPYLGLYCINE ,98% min
  • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic acid - [F91498]
  • Fmoc-CyclopropylGly-OH
  • 1212257-18-5
  • Unusual amino acids
  • a-amino