2-AMINO-5-FLUOROBENZAMIDE
- Product Name
- 2-AMINO-5-FLUOROBENZAMIDE
- CAS No.
- 63069-49-8
- Chemical Name
- 2-AMINO-5-FLUOROBENZAMIDE
- Synonyms
- 5-FLUOROANTHRANILAMIDE;2-AMINO-5-FLUOROBENZAMIDE;Benzamide, 2-amino-5-fluoro-;2-Amino-5-fluorobenzamide97%;2-Amino-5-fluorobenzamide 97%;2-Amino-5-fluorobenzamide, >=98%;2-Carbamoyl-4-fluoroaniline, 5-Fluoroanthranilamide
- CBNumber
- CB6416306
- Molecular Formula
- C7H7FN2O
- Formula Weight
- 154.14
- MOL File
- 63069-49-8.mol
2-AMINO-5-FLUOROBENZAMIDE Property
- Melting point:
- 143-148℃
- Boiling point:
- 259.3±25.0 °C(Predicted)
- Density
- 1.344±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 15.23±0.50(Predicted)
- form
- Crystalline
- color
- Off-white
- InChI
- InChI=1S/C7H7FN2O/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H2,10,11)
- InChIKey
- RHJMYIPLYKQZJM-UHFFFAOYSA-N
- SMILES
- C(N)(=O)C1=CC(F)=CC=C1N
- CAS DataBase Reference
- 63069-49-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A3181
- Product name
- 2-Amino-5-fluorobenzamide
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- A617560
- Product name
- 2-Amino-5-fluoro-benzamide
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA70235
- Product name
- 2-Amino-5-fluorobenzamide
- Packaging
- 50g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- L183
- Product name
- 2-Amino-5-fluorobenzamide
- Packaging
- 25g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- L183
- Product name
- 2-Amino-5-fluorobenzamide
- Packaging
- 50g
- Price
- $387
- Updated
- 2021/12/16
2-AMINO-5-FLUOROBENZAMIDE Chemical Properties,Usage,Production
Uses
2-Amino-5-fluoro-benzamide?is a useful reagent to prepare various quinazolinones including the enantioselective synthesis of fluoro-dihydroquinazolones and -benzooxazinones.
Synthesis
446-08-2
63069-49-8
General procedure for the synthesis of 2-amino-5-fluorobenzamide from 2-amino-5-fluorobenzoic acid: A solution of 2-amino-5-fluorobenzoic acid (3 g, 19.34 mmol) in tetrahydrofuran (64.5 mL) was added to a round-bottomed flask, and a toluene solution of 20% phosgene (11.2 mL, 21.3 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature for 18 h. The mixture was subsequently cooled to 0 °C and concentrated ammonium hydroxide solution (27.9 mL, 193 mmol) was carefully added. The mixture was gradually warmed to room temperature and stirring was continued for 1 hour. After completion of the reaction, the organic phase was diluted with ethyl acetate, washed sequentially with aqueous dipotassium hydrogen phosphate and saturated brine, dried over anhydrous sodium sulfate and concentrated to give the white solid product 2-amino-5-fluorobenzamide (2.46 g, 82% yield). Mass spectral data: M(C7H7FN2O) = 154.14, (M + H - NH3)+ = 138.
References
[1] Patent: US2008/182852, 2008, A1. Location in patent: Page/Page column 28
[2] Molecules, 2017, vol. 22, # 2,
[3] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 77
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 23, p. 4479 - 4487
[5] Patent: US6479499, 2002, B1
2-AMINO-5-FLUOROBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-5-FLUOROBENZAMIDE manufacturers
- Product
- 2-AMINO-5-FLUOROBENZAMIDE 63069-49-8
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-05
- Product
- 2-Amino-5-fluorobenzamide 63069-49-8
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-29
- Product
- 2-Amino-5-fluorobenzamide 63069-49-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-16