ASTRESSIN
- Product Name
- ASTRESSIN
- CAS No.
- 170809-51-5
- Chemical Name
- ASTRESSIN
- Synonyms
- ASTRESSIN;Astressin TFA;ASTRESSIN (HUMAN, RAT);Astressin >=90% (HPLC);M.W. 3563.24 C161H269N49O42;ASTRESSIN TRIFLUOROACETATE SALT;[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT);[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT;[D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41;(D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT
- CBNumber
- CB6437677
- Molecular Formula
- C161H269N49O42
- Formula Weight
- 3563.16
- MOL File
- 170809-51-5.mol
ASTRESSIN Property
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in 10% Acetic acid / water
- Sequence
- H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A4933
- Product name
- Astressin
- Purity
- ≥90% (HPLC)
- Packaging
- 0.5mg
- Price
- $663
- Updated
- 2024/03/01
- Product number
- 1606
- Product name
- Astressin
- Packaging
- 500U
- Price
- $363
- Updated
- 2021/12/16
- Product number
- A2298-41
- Product name
- Astressin
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- B5147
- Product name
- Astressin
- Packaging
- 1mg
- Price
- $567
- Updated
- 2021/12/16
- Product number
- FA108999
- Product name
- Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt
- Packaging
- 1mg
- Price
- $479
- Updated
- 2021/12/16
ASTRESSIN Chemical Properties,Usage,Production
Uses
Astressin has been used as a CRF-receptor antagonist to study its effects on the decrease in the Schaffer collateral-CA1 field potential induced by hypoxia/hypoglycemia (ischemia) in rat hippocampal slices.
Definition
ChEBI: A 30-membered homodetic cyclic peptide comprising the sequence D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 cyclised by an amide bridge, ormed by condensation of the side-chain carboxy group of the Glu residue at position 19 and the side-chain amino group of the Lys residue at position 22.
Biochem/physiol Actions
Astressin is a non-selective corticotropin releasing factor (CRF)-receptor antagonist. It potentially blocks CRF-induced adrenocorticotropic hormone (ACTH) release. Astressin effectively deceases delayed effects of chronic social isolation such as anxiety and fobial states in rats.
Enzyme inhibitor
This novel CRF antagonist (MW = 3663.20 g/mol; CAS 170809-51-5; Sequence: D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala- Glu-Gln-Ala-Gln-cyclo-(g-Glu-Ala-His-e-Lys)Asn-Arg-Leu-Leu-Mle-Glu- Ile-Ile-NH2; Solubility: 1 mg/mL in Acetic acid/water (10% vol/vol); Alternate Name: [D-Phe 12 , Nle 21,38 , Glu30 , Lys 33 ]-CRF) targets human Corticotropin-Releasing hormone (CRH) Receptor subtypes CRF2α (Ki = 1.5 nM) and CRF2β (Ki = 1 nM), with a comparable value (2 nM) for CRF1. (See also Antisauvagine-30; K41448) These type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Astressin is a structurally constrained and competitive antagonists of corticotropin- releasing factor. Astressin is neuroprotective in the hippocampus when administered after a seizure. Peripheral injection of astressin blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. A related antagonist is Astressin 2B (FW = 4041.69 g/mol; CAS 681260-70-8; Sequence: Ac-Asp-Leu-Ser-D-Phe-His-a-methyl-Leu-Leu- Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala- cyclo-(g-Glu-Ala-Asn-e-Lys)Leu-Leu-Leu-Asp-a-methyl-Leu-Ile-NH2). Astressin 2B is a potent and selective antagonist of CRF2 (IC50 = 1.3 nM) and CRF1 (IC50 > 500 nM).
storage
Store at -20°C
ASTRESSIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ASTRESSIN manufacturers
- Product
- Astressin-B 170809-51-5
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2022-11-02
- Product
- ASTRESSIN 170809-51-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13