ChemicalBook > CAS DataBase List > ASTRESSIN

ASTRESSIN

Product Name
ASTRESSIN
CAS No.
170809-51-5
Chemical Name
ASTRESSIN
Synonyms
ASTRESSIN;Astressin TFA;ASTRESSIN (HUMAN, RAT);Astressin >=90% (HPLC);M.W. 3563.24 C161H269N49O42;ASTRESSIN TRIFLUOROACETATE SALT;[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT);[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT;[D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41;(D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT
CBNumber
CB6437677
Molecular Formula
C161H269N49O42
Formula Weight
3563.16
MOL File
170809-51-5.mol
More
Less

ASTRESSIN Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
−20°C
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 1 mg/ml in 10% Acetic acid / water
Sequence
H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A4933
Product name
Astressin
Purity
≥90% (HPLC)
Packaging
0.5mg
Price
$663
Updated
2024/03/01
Tocris
Product number
1606
Product name
Astressin
Packaging
500U
Price
$363
Updated
2021/12/16
Usbiological
Product number
A2298-41
Product name
Astressin
Packaging
1mg
Price
$531
Updated
2021/12/16
ApexBio Technology
Product number
B5147
Product name
Astressin
Packaging
1mg
Price
$567
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA108999
Product name
Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt
Packaging
1mg
Price
$479
Updated
2021/12/16
More
Less

ASTRESSIN Chemical Properties,Usage,Production

Uses

Astressin has been used as a CRF-receptor antagonist to study its effects on the decrease in the Schaffer collateral-CA1 field potential induced by hypoxia/hypoglycemia (ischemia) in rat hippocampal slices.

Definition

ChEBI: A 30-membered homodetic cyclic peptide comprising the sequence D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 cyclised by an amide bridge, ormed by condensation of the side-chain carboxy group of the Glu residue at position 19 and the side-chain amino group of the Lys residue at position 22.

Biochem/physiol Actions

Astressin is a non-selective corticotropin releasing factor (CRF)-receptor antagonist. It potentially blocks CRF-induced adrenocorticotropic hormone (ACTH) release. Astressin effectively deceases delayed effects of chronic social isolation such as anxiety and fobial states in rats.

Enzyme inhibitor

This novel CRF antagonist (MW = 3663.20 g/mol; CAS 170809-51-5; Sequence: D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala- Glu-Gln-Ala-Gln-cyclo-(g-Glu-Ala-His-e-Lys)Asn-Arg-Leu-Leu-Mle-Glu- Ile-Ile-NH2; Solubility: 1 mg/mL in Acetic acid/water (10% vol/vol); Alternate Name: [D-Phe 12 , Nle 21,38 , Glu30 , Lys 33 ]-CRF) targets human Corticotropin-Releasing hormone (CRH) Receptor subtypes CRF2α (Ki = 1.5 nM) and CRF2β (Ki = 1 nM), with a comparable value (2 nM) for CRF1. (See also Antisauvagine-30; K41448) These type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Astressin is a structurally constrained and competitive antagonists of corticotropin- releasing factor. Astressin is neuroprotective in the hippocampus when administered after a seizure. Peripheral injection of astressin blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. A related antagonist is Astressin 2B (FW = 4041.69 g/mol; CAS 681260-70-8; Sequence: Ac-Asp-Leu-Ser-D-Phe-His-a-methyl-Leu-Leu- Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala- cyclo-(g-Glu-Ala-Asn-e-Lys)Leu-Leu-Leu-Asp-a-methyl-Leu-Ile-NH2). Astressin 2B is a potent and selective antagonist of CRF2 (IC50 = 1.3 nM) and CRF1 (IC50 > 500 nM).

storage

Store at -20°C

ASTRESSIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ASTRESSIN Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
968
Advantage
59
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hangzhou Peptide Biochem Co.,Ltd
Tel
0571-89197072; 18668118770
Fax
0571-89197072
Email
linda@peptide-china.com
Country
China
ProdList
248
Advantage
56
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4809
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
+86-15542445688
Fax
0086-411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
992
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Hebei Yanxi Chemical Co., Ltd.
Tel
+8617531153977
Email
allison@yan-xi.com
Country
China
ProdList
5857
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5173
Advantage
58
Hangzhou Xinhai Pharmaceutical Technology Co., Ltd.
Tel
0571-86758863 13867485072
Fax
0571-86758863
Email
lulu@thinheal.com
Country
China
ProdList
302
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29810
Advantage
58
Nanjing chengqimei Biotechnology Co., Ltd
Tel
19850819832
Email
2173594524@qq.com
Country
China
ProdList
2638
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Nanchang Tianzhen Biotechnology Co., Ltd
Tel
13173652190
Email
pomy@tanzhenbio.com
Country
China
ProdList
1790
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
2890
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31121
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Email
alan.chow@synzest.com
Country
China
ProdList
9470
Advantage
58
Chengdu Jinglin Biotechnology Co., Ltd.
Tel
17711399154
Email
3211919385@qq.com
Country
China
ProdList
1815
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
Country
China
ProdList
5178
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6659
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29976
Advantage
58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Tel
0571-85350119 15888826472
Email
15888826472@163.com
Country
China
ProdList
2729
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4604
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
13770887460
Email
wenxi@jszkhy.com
Country
China
ProdList
1349
Advantage
58
Combio (Suzhou) Ltd.
Tel
0512-51886999 17706251929
Email
office@combiosz.com
Country
China
ProdList
2979
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29979
Advantage
58
Shanghai Toyang Biotechnology Co., LTD
Tel
021-59555769 13524932310
Fax
021-50342869
Email
1405894150@qq.com
Country
China
ProdList
8221
Advantage
58
Nanjing Yushengkang Biotechnology Co., Ltd
Tel
13327808530
Email
2670965693@qq.com
Country
China
ProdList
2179
Advantage
58
Zhejiang Jiekun Biotechnology Co., Ltd
Tel
0571-88211951 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
4904
Advantage
58
Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983 19135651983
Email
18611134419@163.com
Country
China
ProdList
4416
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Hangzhou Beiputai Biopharmaceutical Co., Ltd
Tel
0571-85350119 15888826472
Email
bptsales@163.com
Country
China
ProdList
3851
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-81148929 13186179623
Email
1049@dideu.com
Country
China
ProdList
10011
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-02759101766 13125137661
Email
2853877621@qq.com
Country
China
ProdList
6107
Advantage
58
Changsha MOL Changes Biotechnology Co., Ltd.
Tel
+8619375158599
Email
info@molchanges.com
Country
China
ProdList
5223
Advantage
58
More
Less

View Lastest Price from ASTRESSIN manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Astressin-B 170809-51-5
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
20 tons
Release date
2022-11-02
Career Henan Chemical Co
Product
ASTRESSIN 170809-51-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

170809-51-5, ASTRESSINRelated Search:


  • Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt
  • H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2
  • M.W. 3563.24 C161H269N49O42
  • DPHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLU-ALA-HIS-LYS-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2
  • D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 (LactaM bridge Glu30-Lys33)
  • H-D-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-CYCLO(-GAMMA-GLU-ALA-HIS-EPSILON-LYS)-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2
  • [D-PHE12, NLE21,38, GLU30, LYS33]-CORTICOTROPIN RELEASING FACTOR (12-41) (HUMAN, RAT)
  • [D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41
  • [D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT
  • [D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT)
  • (D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41)(HUMAN, RAT) (CYCLIZED BETWEEN GAMMA-GLU30 ANDEPSILON-LYS33)
  • (D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT
  • D-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLU-ALA-HIS-LYS-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2
  • ASTRESSIN
  • ASTRESSIN (HUMAN, RAT)
  • ASTRESSIN TRIFLUOROACETATE SALT
  • L-Isoleucinamide, D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-histidyl-L-lysyl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-norl...
  • Astressin >=90% (HPLC)
  • L-Isoleucinamide,D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-a-glutamyl-L-valyl-L-leucyl-L-a-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-a-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-
  • Astressin TFA
  • 170809-51-5
  • C161H269N49O42
  • CRF
  • Peptides
  • Releasing Factors
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • CRF receptor and related