4-BROMO-7-METHOXY-1H-INDOLE
- Product Name
- 4-BROMO-7-METHOXY-1H-INDOLE
- CAS No.
- 436091-59-7
- Chemical Name
- 4-BROMO-7-METHOXY-1H-INDOLE
- Synonyms
- 4-BroMo-7-Methoxyindole;4-BROMO-7-METHOXY-1H-INDOLE;1H-Indole, 4-broMo-7-Methoxy-;4-Bromo-7-methoxy-1H-indole, 96%
- CBNumber
- CB6438184
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 436091-59-7.mol
4-BROMO-7-METHOXY-1H-INDOLE Property
- Boiling point:
- 356.5±22.0 °C(Predicted)
- Density
- 1.591±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 15.56±0.30(Predicted)
- Appearance
- Light yellow to brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B292860
- Product name
- 4-Bromo-7-methoxy-1H-indole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Z4755
- Product name
- 4-Bromo-7-methoxy-1H-indole
- Packaging
- 25g
- Price
- $3155
- Updated
- 2021/12/16
- Product number
- Z4755
- Product name
- 4-Bromo-7-methoxy-1H-indole
- Packaging
- 1g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- 112688
- Product name
- 4-Bromo-7-methoxy-1H-indole
- Packaging
- 1g
- Price
- $465
- Updated
- 2021/12/16
- Product number
- CM107997
- Product name
- 1h-indole,4-bromo-7-methoxy-
- Purity
- 95%
- Packaging
- 5g
- Price
- $636
- Updated
- 2021/12/16
4-BROMO-7-METHOXY-1H-INDOLE Chemical Properties,Usage,Production
Uses
4-BROMO-7-METHOXY-1H-INDOLE has garnered interest due to its potential biological activities and applications in the synthesis of pharmaceuticals and organic chemistry, serving as a valuable building block and chemical intermediate.
Synthesis
33696-00-3
1826-67-1
436091-59-7
Example 13 Synthesis of 4-bromo-7-methoxyindole (LII): to a tetrahydrofuran (THF) solution (300 ml) of 4-bromo-2-nitroanisole (7.89 g, 33.3 mmol) was slowly added vinylmagnesium bromide (1 M in THF) at -60 °C. The reaction temperature was kept below -40 °C while the reaction mixture was stirred so that the temperature was gradually raised to -40 °C within 2 hours. After completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution (100 ml, 0.1 mol). The aqueous phase was extracted with ether (Et2O, 200 ml), the organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated. Finally, the target product 4-bromo-7-methoxyindole (LII, 594 mg, 8% yield) was purified by fast chromatography.
References
[1] Patent: WO2009/62285, 2009, A1. Location in patent: Page/Page column 111
[2] Patent: US2007/123527, 2007, A1. Location in patent: Page/Page column 67-68
4-BROMO-7-METHOXY-1H-INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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