3-CHLORO-5-METHOXYPYRIDAZINE
- Product Name
- 3-CHLORO-5-METHOXYPYRIDAZINE
- CAS No.
- 123696-02-6
- Chemical Name
- 3-CHLORO-5-METHOXYPYRIDAZINE
- Synonyms
- 3-CHLORO-5-METHOXYPYRIDAZINE;Pyridazine, 3-chloro-5-methoxy-;3-Chloro-5-Methoxypyridazine HCl;3-Chloro-5-methoxypyridazine, HCl salt;3-CHLORO-5-METHOXYPYRIDAZINE ISO 9001：2015 REACH
- CBNumber
- CB6444316
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 123696-02-6.mol
3-CHLORO-5-METHOXYPYRIDAZINE Property
- Boiling point:
- 285 ºC
- Density
- 1.292
- Flash point:
- 126 ºC
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.45±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H5ClN2O/c1-9-4-2-5(6)8-7-3-4/h2-3H,1H3
- InChIKey
- XLGRINRFBNCHQS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NN=CC(OC)=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368715
- Product name
- 3-Chloro-5-methoxypyridazine
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- C368715
- Product name
- 3-Chloro-5-methoxypyridazine
- Packaging
- 5G
- Price
- $660
- Updated
- 2021/12/16
- Product number
- FC46391
- Product name
- 3-Chloro-5-methoxypyridazine
- Packaging
- 5G
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FC46391
- Product name
- 3-Chloro-5-methoxypyridazine
- Packaging
- 10g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 113085
- Product name
- 3-Chloro-5-methoxypyridazine
- Packaging
- 5g
- Price
- $780
- Updated
- 2021/12/16
3-CHLORO-5-METHOXYPYRIDAZINE Chemical Properties,Usage,Production
Uses
3-Chloro-5-methoxypyridazine is used to synthesize potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy.
Synthesis
123696-01-5
123696-02-6
5-Methoxypyridazin-3(2H)-one (250 mg, 1.98 mmol) was used as starting material and suspended in phosphoryl chloride (1.5 mL, 16 mmol). The reaction mixture was stirred at 100 °C for 10 min. After completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to alkaline by adding sodium carbonate. Subsequently, the mixture was extracted with ether and the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure. The resulting residue was recrystallized with 1,2-dichloroethane to give 130 mg of 3-chloro-5-methoxypyridazine in 45% yield. The product was analyzed by LC-MS (Method 5): r = 0.85 mm; MS (ESIpos): m/z = 145 [M + H]+. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 2.495 (0.78), 2.499 (1.07), 2.503 (0.84), 3.317 (11.94). 3.944 (16.00), 7.528 (2.28), 7.534 (2.29), 8.988 (2.34), 8.994 (2.34).
References
[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 5, p. 1473 - 1476
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 19, p. 4716 - 4730
[3] Monatshefte fuer Chemie, 1989, vol. 120, p. 329 - 342
[4] Patent: WO2017/102091, 2017, A1. Location in patent: Page/Page column 455; 456
3-CHLORO-5-METHOXYPYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-5-METHOXYPYRIDAZINE manufacturers
- Product
- 3-CHLORO-5-METHOXYPYRIDAZINE 123696-02-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18
- Product
- 3-Chloro-5-methoxypyridazine 123696-02-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 50kgs/month
- Release date
- 2022-05-10
- Product
- 3-CHLORO-5-METHOXYPYRIDAZINE 123696-02-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02