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L-CYSTATHIONINE

Product Name
L-CYSTATHIONINE
CAS No.
56-88-2
Chemical Name
L-CYSTATHIONINE
Synonyms
L-CYSTATHIONINE;L(+)CYSTATHIONINE;CYSTATHIONINE, L-;L-Cystathionine (P);L-Cystathionine Standard;L-CYSTATHIONINE, >= 98% (TLC);CYSTATHIONINE, L-(DS)(REQUEST QUOTE);(2R,7S)-2,7-Diamino-4-thiaoctanedioic acid;[R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE;S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine
CBNumber
CB6446239
Molecular Formula
C7H14N2O4S
Formula Weight
222.26
MOL File
56-88-2.mol
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L-CYSTATHIONINE Property

Melting point:
312
alpha 
D20 +23.7° (1N HCl)
Density 
1.430±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
Aqueous Acid (Slightly)
form 
Solid
Boiling point:
481.0±45.0 °C(Predicted)
pka
2.08±0.10(Predicted)
color 
White to Off-White
optical activity
+26.425 (1 mol dm-3 HCl)
Merck 
13,2807
BRN 
2505200
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Safety

WGK Germany 
3
F 
10-21
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7505
Product name
L-Cystathionine
Purity
≥98% (TLC)
Packaging
10mg
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
C7505
Product name
L-Cystathionine
Purity
≥98% (TLC)
Packaging
50mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
16061
Product name
L-(+)-Cystathionine
Purity
≥98%
Packaging
5mg
Price
$46
Updated
2024/03/01
Cayman Chemical
Product number
16061
Product name
L-(+)-Cystathionine
Purity
≥98%
Packaging
10mg
Price
$74
Updated
2024/03/01
Sigma-Aldrich
Product number
C7505
Product name
L-Cystathionine
Purity
≥98% (TLC)
Packaging
250mg
Price
$1520
Updated
2024/03/01
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L-CYSTATHIONINE Chemical Properties,Usage,Production

Description

L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.

Chemical Properties

White Crystalline Solid

Uses

Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine

Uses

L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.

Definition

ChEBI: L-cystathionine is a modified amino acid generated by enzymic means from L-homocysteine and L-serine. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a tautomer of a L-cystathionine dizwitterion.

Biochem/physiol Actions

L-Cystathionine is an intermediate in the biosynthesis of L-cysteine and methionine. It is used as a substrate to differentiate and analyze cystathionine γ-lyase(s). L-Cystathionine is an important non-protein amino acid and is associated with metabolic disorders. In recent studies, L-cystathionine is believed to be the precursor of cyclic imino acid cyclothionine. Cystathioninuria is characterized with imino acid cyclothionine excretion in the urine.

Purification Methods

S,S-Cystathionine is purified by converting it to the HCl salt in 20% HCl and carefully basifying with aqueous NH3 until separation is complete. Filter it off and dry it in a vacuum. It forms prisms from H2O. The dibenzoyl derivative has m 229o (from EtOH). [IR: Greenstein & Winitz Chemistry of the Amino Acids (J Wiley) Vol 3 p2690 1961 and Tallan et al. J Biol Chem 230 707 1958, Synthesis: du Vigneaud et al. J Biol Chem 143 59 1942, Anslow et al. J Biol Chem 166 39 1946.] [Prepn: Weiss & Stekol J Am Chem Soc 73 2497 1951; see also du Vigneaud et al. J Biol Chem 143 60 1942, Biological synthesis: Greenberg Methods Enzymol 5 943 1962, Beilstein 4 IV 3197.]

L-CYSTATHIONINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-CYSTATHIONINE manufacturers

Career Henan Chemical Co
Product
L-Cystathionine 56-88-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

56-88-2, L-CYSTATHIONINERelated Search:

CYSTATHIONINE, D-(P),CYSTATHIONINE, L-(RG) D,L-CYSTATHIONINE,dl,dl-allo-cystathionine,CYSTATHIONINE,DL,DL-allo-Cystathionine, S-(2-Amino-2-carboxyethyl)homocysteine L-CYSTATHIONINE DI-FMOC-L-CYSTATHIONINE BUTANOIC ACID, 2-AMINO-4-[(S)-[(2R)-2-AMINO-2-CARBOXYETHYL]SULFINYL]-, (2S)- DI-BOC-L-CYSTATHIONINE L-Cystathionine -lyase CYSTATHIONINE, D-,D-CYSTATHIONINE Cystathionine beta-Synthase DI-FMOC-DL-CYSTATHIONINE DI-BOC-DL-CYSTATHIONINE DL-Allocystathionine CYSTATHIONINE 10MG [R] Cystathionine ketimine Cystathionine sulfoxide Cystathionine gamma-Lyase Cyclic cystathionine cystathionine beta-lyase

  • CYSTATHIONINE, L-
  • L(+)CYSTATHIONINE
  • L-CYSTATHIONINE
  • L-CYSTATHIONINE, >= 98% (TLC)
  • [R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE
  • (2S)-2-amino-4-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanylbutanoic acid
  • L-Cystathionine,(R)-S-(2-Amino-2-carboxyethyl)-L-homocysteine
  • (2S)-2-Amino-4-{[(2R)-2-amino-2-carboxyethyl]thio}butanoic acid
  • [R-(R*,S*)]-2-AMino-4-[(2-aMino-2-carboxyethyl)thio]butanoic Acid
  • S-[(2R)-2-AMino-2-carboxyethyl]-L-hoMocysteine
  • CYSTATHIONINE, L-(DS)(REQUEST QUOTE)
  • (2R,7S)-2,7-Diamino-4-thiaoctanedioic acid
  • S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine
  • L-Homocysteine, S-[(2R)-2-amino-2-carboxyethyl]-
  • L-Cystathionine Standard
  • L-Cystathionine (P)
  • 56-88-2
  • Amino Acid Library
  • BioChemical
  • Metabolic Libraries
  • Metabolomics
  • Cysteine Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Intermediates
  • Sulfur & Selenium Compounds