ISOXADIFEN-ETHYL
- Product Name
- ISOXADIFEN-ETHYL
- CAS No.
- 163520-33-0
- Chemical Name
- ISOXADIFEN-ETHYL
- Synonyms
- aef122006;Isoxadifen etil;ISOXADIFEN-ETHYL;Dibenzoxazolic acid;Diphenyloxazolic acid;Isoxadifen ethyl ester;C14480500 Isoxadifen-ethyl;isoxadifen-ethyl(bsi,pa iso);Isoxadifen-ethyl 10.0 μg/ml Acetonitrile;Isoxadifen-ethyl 10 μg/mL in Cyclohexane
- CBNumber
- CB6458584
- Molecular Formula
- C18H17NO3
- Formula Weight
- 295.33
- MOL File
- 163520-33-0.mol
ISOXADIFEN-ETHYL Property
- Melting point:
- 87-88℃ (ethyl ether )
- Boiling point:
- 407.7±55.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3 (20 ºC 760 Torr)
- vapor pressure
- 0Pa at 20℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- color
- White to Almost white
- Water Solubility
- 1.06mg/L at 20℃
- InChI
- InChI=1S/C18H17NO3/c1-2-21-17(20)16-13-18(22-19-16,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12H,2,13H2,1H3
- InChIKey
- MWKVXOJATACCCH-UHFFFAOYSA-N
- SMILES
- O1C(C2=CC=CC=C2)(C2=CC=CC=C2)CC(C(OCC)=O)=N1
- LogP
- 3.8 at 30℃
- EPA Substance Registry System
- Isoxadifen-ethyl (163520-33-0)
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-43-50-50/53
- Safety Statements
- 36/37-61-60-22
- RIDADR
- UN3077 9/PG 3
- WGK Germany
- 3
- RTECS
- NY2390000
- HS Code
- 2934.99.1800
- HazardClass
- 9
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- CRM33799
- Product name
- Isoxadifen-ethyl
- Purity
- certified reference material, <I>Trace</I><B>CERT</B><SUP>®</SUP>, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
- Packaging
- 50 mg
- Price
- $81.1
- Updated
- 2025/07/31
- Product number
- 33799
- Product name
- Isoxadifen-ethyl
- Purity
- PESTANAL
- Packaging
- 100mg
- Price
- $234
- Updated
- 2025/07/31
- Product number
- I0956
- Product name
- Isoxadifen-ethyl
- Packaging
- 5G
- Price
- $100
- Updated
- 2025/07/31
- Product number
- I0956
- Product name
- Isoxadifen-ethyl
- Packaging
- 25G
- Price
- $297
- Updated
- 2025/07/31
- Product number
- I918223
- Product name
- Isoxadifen-ethyl
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
ISOXADIFEN-ETHYL Chemical Properties,Usage,Production
Uses
Isoxadifen-ethyl is a particularly useful pesticide.
Definition
ChEBI: Isoxadifen-ethyl is an isoxazoline that is the ethyl ester of isoxadifen. It is used as a herbicide safener, especially in conjunction with the herbicides fenoxaprop-P-ethyl and iodosulfuron-methyl-sodium. It is not approved for use within the European Union. It has a role as a herbicide safener and an agrochemical. It is an ethyl ester and an isoxazoline. It is functionally related to an isoxadifen.
Preparation
Isoxadifen-ethyl is prepared by reacting 1, 1-diphenyl ethylene and ethyl 2-chloro-2-(hydroxyimino)acetate under the action of alkali metal compounds. The reaction process is as follows:
Flammability and Explosibility
Non flammable
Synthesis
67428-04-0
163520-33-0
Ethyl 2,2-diphenylcyclopropanecarboxylate (0.97 g, 3.7 mmol) was dissolved in 3.7 mL of trifluoroacetic acid (CF3CO2H). Sodium nitrite (NaNO2, 0.28 g, 4.0 mmol, 1.1 eq.) was added to the solution in batches under controlled reaction temperature not exceeding 40 °C. After addition, the reaction mixture was stirred at room temperature (about 18 °C) for 30 minutes. Subsequently, the reaction mixture was poured into ice water and extracted with ether (2 x 20 mL). The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) (2 x 20 mL), water (20 mL) and brine (20 mL). The washed organic phase was dried with anhydrous sodium sulfate (Na2SO4). After filtration to remove the desiccant, the organic phase was concentrated under reduced pressure to give a light brown oily crude product. 1H NMR analysis of the crude product showed complete reaction with 100% yield. The crude product was further purified by silica gel column chromatography (Rf: 0.45, eluent: petroleum ether solution of 20% ethyl acetate) to afford ethyl 5,5-diphenyl-4,5-dihydroisoxazole-3-carboxylate (0.958 g, 89% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 7.41-7.26 (m, 10H), δ 4.34 (q, J = 7.1 Hz, 2H), 3.86 (s, 2H), 1.36 (t, J = 7.1 Hz, 3H). 13C NMR (400 MHz, CDCl3): δ 160.54, 151.09, 142.99, 128.54, 128.02, 125.95, 94.79, 62.15, 46.78 14.12.
References
[1] Patent: US2016/60223, 2016, A1. Location in patent: Paragraph 0022
ISOXADIFEN-ETHYL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ISOXADIFEN-ETHYL manufacturers
- Product
- Isoxadifen-ethyl 163520-33-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2025-09-28
- Product
- Isoxadifen-ethyl 163520-33-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%HPLC
- Supply Ability
- EX:100 tons
- Release date
- 2025-02-14
- Product
- ISOXADIFEN-ETHYL 163520-33-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04