2,4-DIFLUORO-3-METHYLBENZOIC ACID
- Product Name
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID
- CAS No.
- 112857-68-8
- Chemical Name
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID
- Synonyms
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID;Benzoic acid, 2,4-difluoro-3-Methyl-
- CBNumber
- CB6463193
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 112857-68-8.mol
2,4-DIFLUORO-3-METHYLBENZOIC ACID Property
- Boiling point:
- 253.1±35.0 °C(Predicted)
- Density
- 1.359±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.28±0.10(Predicted)
- CAS DataBase Reference
- 112857-68-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D448383
- Product name
- 2,4-Difluoro-3-methylbenzoicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D448383
- Product name
- 2,4-Difluoro-3-methylbenzoicacid
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- HCH0062962
- Product name
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $480
- Updated
- 2021/12/16
- Product number
- HCH0062962
- Product name
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $655
- Updated
- 2021/12/16
- Product number
- X9035
- Product name
- 2,4-Difluoro-3-methylbenzoicacid
- Packaging
- 10g
- Price
- $663
- Updated
- 2021/12/16
2,4-DIFLUORO-3-METHYLBENZOIC ACID Chemical Properties,Usage,Production
Synthesis
74-88-4
1583-58-0
112857-68-8
1. To a stirred solution of diisopropylamine (1.7 g, 16.4 mmol) in anhydrous THF (30 mL) was slowly added a 2.6 M solution of n-butyllithium (n-BuLi, 1.1 g, 16.4 mmol) under nitrogen protection, the reaction temperature was maintained at -30 °C, and stirring was continued for 1 h at this temperature. 2. The reaction system was cooled to -78 °C and a solution of anhydrous THF (10 mL) of 2,4-difluorobenzoic acid (1.0 g, 6.3 mmol) was added slowly and dropwise, followed by the addition of iodomethane (2.2 g, 15.7 mmol). 3. The reaction mixture was gradually warmed to 50 °C and stirred at this temperature for 2 hours. 4. Upon completion of the reaction, the mixture was returned to room temperature and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution. 5. The aqueous layer was separated and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). 6. Concentrate under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography, the eluent being a solvent mixture of ethyl acetate/petroleum ether. 7. The target fraction was collected and concentrated under reduced pressure to give a white solid product, 2,4-difluoro-3-methylbenzoic acid (0.77 g, 70% yield). 8. The product was characterized by mass spectrometry (ESI) m/z: 172 [M+H]+, corresponding to the molecular formula C8H6F2O2; 1H NMR (400 MHz, CDCl3) δ: 2.2 (s, 3H), 7.0 (m, 1H), 7.9 (m, 1H).
References
[1] Patent: WO2010/43893, 2010, A1. Location in patent: Page/Page column 99-100
2,4-DIFLUORO-3-METHYLBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DIFLUORO-3-METHYLBENZOIC ACID Suppliers
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 18049974220
- Fax
- +86 (21) 51062076
- 3060526242@qq.com
- Country
- China
- ProdList
- 995
- Advantage
- 60
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- +1-510-219-6317
- Fax
- +1-650-486-1361
- sales@hbcchem.com
- Country
- United States
- ProdList
- 10648
- Advantage
- 60
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
View Lastest Price from 2,4-DIFLUORO-3-METHYLBENZOIC ACID manufacturers
- Product
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID 112857-68-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09