ChemicalBook > CAS DataBase List > 5-Azacytosine

5-Azacytosine

Product Name
5-Azacytosine
CAS No.
931-86-2
Chemical Name
5-Azacytosine
Synonyms
4-aMino-1,3,5-triazin-2-ol;4-amino-1,3,5-triazin-2(1h)-one;AZACYTOSINE;NSC 51100;NSC 54006;5-Azacytosin;5 zacytosine;5-AZACYTOSINE;5-Azacytosine,98%;5-Azacytosine API
CBNumber
CB6465182
Molecular Formula
C3H4N4O
Formula Weight
112.09
MOL File
931-86-2.mol
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5-Azacytosine Property

Melting point:
>300 °C (lit.)
Boiling point:
209.98°C (rough estimate)
Density 
1.86
refractive index 
1.8010 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
form 
Solid
pka
7.61±0.10(Predicted)
color 
White to Off-White
BRN 
116378
InChI
InChI=1S/C3H4N4O/c4-2-5-1-6-3(8)7-2/h1H,(H3,4,5,6,7,8)
InChIKey
MFEFTTYGMZOIKO-UHFFFAOYSA-N
SMILES
N1C(N)=NC=NC1=O
CAS DataBase Reference
931-86-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
XZ2854300
HS Code 
29336990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3473
Product name
Azacitidine Related Compound A
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$651
Updated
2025/07/31
Sigma-Aldrich
Product number
855049
Product name
5-Azacytosine
Packaging
5g
Price
$80.37
Updated
2025/07/31
Sigma-Aldrich
Product number
1045539
Product name
Azacitidine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1300
Updated
2025/07/31
TCI Chemical
Product number
A1091
Product name
5-Azacytosine Hydrate
Purity
>98.0%(T)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
A1091
Product name
5-Azacytosine Hydrate
Purity
>98.0%(T)
Packaging
25g
Price
$236
Updated
2025/07/31
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5-Azacytosine Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Reactant for:

  • Enzymic synthesis of nucleoside analogs using immobilized 2′-deoxyribosyltransferase from Lactobacillus reuteri
  • Reactions with oxide radical ion

  • Potential antitumor and antiproliferative agent against human leukemia cells

Uses

5-Azacytosine can inhibits the growth of Escherichia coli and used as the most effective cytosine mimics for the design of novel antiviral and anti-tumor drug candidates.

Definition

ChEBI: A monoamino-1,3,5-triazine that is cytosine in which the aromatic CH at position 5 is replaced by a nitrogen.

Synthesis

64-18-6

127099-85-8

931-86-2

(1) Add 1.5Kg of anhydrous formic acid (99.5% purity), 2.5kg of dicyandiamide and 0.005Kg of p-toluenesulfonic acid catalyst to a 10L autoclave. Under the condition of sealing and stirring, the reaction system was slowly warmed up to 110°C and the reaction pressure was maintained. After the reaction was completed, the temperature was slowly cooled down to room temperature to obtain a white solid product. (2) The resulting white solid was transferred to a 50L glass reactor and 10L of dilute hydrochloric acid solution with a mass concentration of 5% was added. Heating was refluxed for 30 minutes until the solution was clarified. Subsequently, the mixture was filtered through a cartridge into a crystallizer. A 30% ammonia solution was added to the crystallizer and the pH was adjusted to 6. White crystals were precipitated. After centrifugation and drying in a hot air oven, 2.8-5 kg of 6-amino-1,3,5-triazin-2(1H)-one (85% yield as dicyandiamide) was finally obtained.

References

[1] Patent: CN105837524, 2016, A. Location in patent: Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048-0079
[2] Chemische Berichte, 1954, vol. 87, p. 19,23
[3] Archiv der Pharmazie (Weinheim, Germany), 1955, vol. 288, p. 139
[4] Patent: CN104402836, 2016, B. Location in patent: Paragraph 0025; 0026; 0027; 0028

5-Azacytosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Azacytosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.
Product
5-azacytosine 931-86-2
Price
US $99.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20Ton
Release date
2025-10-10
HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
5-Azacytosine 931-86-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-08-31
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-Azacytosine 931-86-2
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-29

931-86-2, 5-AzacytosineRelated Search:

4-Aminoacetophenone ANILAZINE 5-METHYLCYTOSINE Toltrazuril beta-Methyl vinyl phosphate (MAP) CHLOROPHOSPHONAZO III 3-Aminoacetophenone ALTRENOGEST Cytosine Metribuzin Fluorocytosine Betaine 2-Aminoacetophenone Glycine 1,3,5-Triazine Buprofezin 5-Azacytidine / 5-Azacytosine 5-Aza-2'-deoxycytidine

  • 5-triazin-2(1h)-one,4-amino-3
  • 2-Amino-4-hydroxy-1,3,5-triazine
  • 2-AMINO-4-HYDROXY-S-TRIAZINE
  • 4-AMINO-1,3,5-TRIAZIN-2-ONE
  • 4-AMINO-1,3,5-TRIAZINE-2[1H]-ONE
  • 4-AMINO-S-TRIAZIN-2(1H)-ONE
  • 5-AZACYTOSINE
  • 5-Azacytosine,98%
  • AZACYTOSINE
  • 4-amino-s-triazin-2-o
  • NSC 51100
  • NSC 54006
  • 5-Azacytosine API
  • 2-Amino-4-hydroxy-1,3,5-triazine 4-Amino-1,3,5-triazin-2(1H)-one
  • 2-AMino-4-hydroxy-1,3,5-triazin
  • AZACYTOSINE, 5-(RG)
  • 4-aMino-1,3,5-triazin-2-ol
  • 4-aMino-1,2-dihydro-1,3,5-triazin-2-one
  • 4-Aino-[1,3,5]triazin-2-ol
  • 5-aza-cytosine, 4-aMino-1,2-dihydro-1,3,5-triazin-2-one, 5-azacytosine
  • 5-Azacytosine&nbsp
  • 5-Azacytosine, 98+% 5GR
  • 1,3,5-Triazin-2(1H)-one, 4-aMino- (9CI)
  • s-Triazin-2(1H)-one, 4-aMino- (8CI)
  • Azacitidine Related CoMpound A
  • Azacitidine Related Compound A (15 mg) (4-Amino-1,3,5-triazin-2(1H)-one)
  • Azacitidine Related Compound C (15 mg) (1-beta-D-Ribofuranosyl-3-guanylurea picrate)
  • 5-Azacytosine(2-amino-4-hydroxy-1,3,5-triazine)
  • Cytosine Impurity 1
  • Decitabine Impurity 49
  • Azacitidine USP Related Compound A
  • Azacetidine Related Compound A (Hydrate)
  • 5-AZACYTOSINE (DRY WT.), MAY CONT. UP TO CA 7% WATER
  • 6-Amino-1H-[1,3,5]triazin-2-one
  • 4-Amino-1H-[1,3,5]triazin-2-one
  • 5-Azacytosine, 98% (dry wt.), may cont. up to ca 7% water
  • 5-Azacytosine Hydrate
  • 2-Hydroxy-4-aminotriazine
  • 4-Amino-2-hydroxy-1,3,5-triazine
  • 4-Amino-2-triazin-2(1H)-one
  • 4-Amino-3H-1,3,5-triazin-2-one
  • 4-Amino-s-triazin-2-ol
  • 4(1H)-Imino-1,3,5-triazine-2-ol
  • 4(3H)-Imino-1,3,5-triazine-2(1H)-one
  • 4(5H)-Imino-1,3,5-triazine-2(3H)-one
  • 4-Amino-1,3,5-triazine-2(3H)-one
  • 4-Amino-1,3,5-triazine-2-ol
  • 4-amino-1,3,5-triazin-2(1h)-one
  • 4-amino-s-triazin-2(1h)-on
  • 5-Azacytosine Hydrate&gt
  • Decitabine Impurity 49 (5-Azacytosine)
  • 1,3,5-Triazin-2(1H)-one, 6-amino-
  • 5-Azacytosine ISO 9001：2015 REACH
  • Decitabine Triazinone Impurity (Azacitidine Related Compound A/ 5-Aza Cytosine)
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  • 1,3,5-Triazin-2(1H)-one, 4-amino-
  • 5-AzacytosineQ: What is 5-Azacytosine Q: What is the CAS Number of 5-Azacytosine Q: What is the storage condition of 5-Azacytosine Q: What are the applications of 5-Azacytosine
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