(+)-D-threo-PDMP (hydrochloride)
- Product Name
- (+)-D-threo-PDMP (hydrochloride)
- CAS No.
- 139889-62-6
- Chemical Name
- (+)-D-threo-PDMP (hydrochloride)
- Synonyms
- (+)-D-threo-PDMP (hydrochloride);(+) D threo PDMP (hydrochloride),(+)DthreoPDMP (hydrochloride)
- CBNumber
- CB64665650
- Molecular Formula
- C23H39ClN2O3
- Formula Weight
- 427.03
- MOL File
- 139889-62-6.mol
(+)-D-threo-PDMP (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- Ethanol: Soluble; Methanol: Soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 10178
- Product name
- (+)-D-threo-PDMP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $469
- Updated
- 2024/03/01
(+)-D-threo-PDMP (hydrochloride) Chemical Properties,Usage,Production
Description
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP .1 (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase.2,3 It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 μM in an enzyme assay.3 (+)-D-threo-PDMP is the active component of racemic DL-threo-PDMP . In vitro, (+)-D-threo-PDMP inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells when used at a concentration of 25 μM and inhibits cell binding to laminin and collagen when used at concentrations of 10 and 25 μM.4 It also inhibits β-1,4-galactosyltransferase 6 (B4GALT6) and prevents lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.5 (+)-D-threo-PDMP inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice.6
References
1. Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain Chem. Phys. Lipids 26(3),265-278(1980).
2. Abe, A., Inokuchi, J.-i., Jimbo, M., et al. Improved inhibitors of glucosylceramide synthase J. Biochem. 111(2),191-196(1992).
3. Inokuchi, J.i., and Radin, N.S. Preparation of the active isomer of 1-
4. Inokuchi, J.-I., Momosaki, K., Shimeno, H., et al. Effects of D-
5. Mayo, L., Trauger, S.A., Blain, M., et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation Nat. Med. 20(10),1147-1156(2014).
6. Fujiwara, H., Ikarashi, K., Yamazaki, Y., et al. Impairment of hippocampal long-
(+)-D-threo-PDMP (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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