8,12-iso-iPF2.alpha.-VI Property

Boiling point:

525.4±50.0 °C(Predicted)

Density 

1.153±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH7.2): .5 mg/ml

pka

4.68±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

8,12-iso-iPF2.alpha.-VI Chemical Properties,Usage,Production

Description

8,12-iso-iPF_2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. It is the most abundant isoprostane product that is formed during lipid peroxidation and is used as a biomarker for oxidative stress.¹ 8,12-iso-iPF_2α-VI is detected after CCl₄-induced oxidative damage to hepatic tissue and has been found elevated in the urine, blood, and cerebrospinal fluid of patients with Alzheimer’s disease.^2,3,4

Definition

ChEBI: 8,12-iso-ipf2alpha-vi is a prostanoid.

References

1. Li, H., Lawson, J.A., Reilly, M., et al. Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine Proc. Natl. Acad. Sci. USA 96(23),13381-13386(1999).
2. Sicilia, T., Mally, A., Schauer, U., et al. LC-MS/MS methods for the detection of isoprostanes (iPF_2α-III and 8,12-iso-iPF_2α-VI) as biomarkers of CCI4-induced oxidative damage to hepatic tissue J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 861(1),48-55(2008).
3. Praticò, D., Clark, C.M., Liun, F., et al. Increase of brain oxidative stress in mild cognitive impairment. A possible predictor of Alzheimer disease Arch. Neurol. 59,972-976(2002).
4. Shaw, L.M., Korecka, M., Clark, C.M., et al. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics Nat. Rev. Drug Discov. 6,295-303(2007).