Protectin D1
- Product Name
- Protectin D1
- CAS No.
- 660430-03-5
- Chemical Name
- Protectin D1
- Synonyms
- NPD1;Protectin D1;Protectin D-1,Protectin D1;4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-
- CBNumber
- CB64666228
- Molecular Formula
- C22H32O4
- Formula Weight
- 360.49
- MOL File
- 660430-03-5.mol
Protectin D1 Property
- Boiling point:
- 559.4±50.0 °C(Predicted)
- Density
- 1.048±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.1 mg/ml
- form
- Liquid
- pka
- 4.58±0.10(Predicted)
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 10010390
- Product name
- Protectin D1
- Purity
- ≥98%
- Packaging
- 10μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 10010390
- Product name
- Protectin D1
- Purity
- ≥98%
- Packaging
- 25μg
- Price
- $273
- Updated
- 2024/03/01
- Product number
- 10010390
- Product name
- Protectin D1
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $513
- Updated
- 2024/03/01
- Product number
- 10010390
- Product name
- Protectin D1
- Purity
- ≥98%
- Packaging
- 100μg
- Price
- $903
- Updated
- 2024/03/01
Protectin D1 Chemical Properties,Usage,Production
Description
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 μg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
Uses
Protectin D1 is a potent anti-inflammatory lipid mediator.
Definition
ChEBI: Protectin D1 is a dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 It has a role as an anti-inflammatory agent, a neuroprotective agent, a PPARgamma agonist, an apoptosis inhibitor, a hepatoprotective agent, a human xenobiotic metabolite and a specialised pro-resolving mediator. It is a dihydroxydocosahexaenoic acid, a secondary allylic alcohol and a protectin.
Protectin D1 Preparation Products And Raw materials
Raw materials
Preparation Products
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