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CAY10706

Product Name
CAY10706
CAS No.
1881270-27-4
Chemical Name
CAY10706
Synonyms
CAY10706;1,4-Pentadien-3-one, 1-(4-hydroxy-3-methoxyphenyl)-5-(3,5,6-trimethyl-2-pyrazinyl)-, (1E,4E)-
CBNumber
CB64666354
Molecular Formula
C19H20N2O3
Formula Weight
324.37
MOL File
1881270-27-4.mol
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CAY10706 Property

Boiling point:
496.8±45.0 °C(Predicted)
Density 
1.198±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml
form 
A crystalline solid
pka
9?+-.0.31(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19318
Product name
CAY10706
Purity
≥95%
Packaging
500μg
Price
$125
Updated
2021/12/16
Cayman Chemical
Product number
19318
Product name
CAY10706
Purity
≥95%
Packaging
1mg
Price
$225
Updated
2021/12/16
Cayman Chemical
Product number
19318
Product name
CAY10706
Purity
≥95%
Packaging
5mg
Price
$788
Updated
2021/12/16
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CAY10706 Chemical Properties,Usage,Production

Description

CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.1 It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 μM), SPC-A-1 (IC50 = 3.12 μM), LTEP-G-2 (IC50 = 2.88 μM)) and drug-resistant (A549/DDP (IC50 = 0.6 μM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 μM)).1 CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.1

References

1. Ai, Y., Zhu, B., Ren, C., et al. Discovery of new monocarbonyl ligustrazine-curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer J. Med. Chem. 59(5),1747-1760(2016).

CAY10706 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10706 Suppliers

China 4 United States 1 Global 5
Shanghai Nafu Biotechnology Co., Ltd.
Tel
021-58952328 13125124762
Fax
021-58952328
Email
sale@chemhui.com
Country
China
ProdList
491
Advantage
55
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7982
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6743
Advantage
58

1881270-27-4, CAY10706Related Search:


  • CAY10706
  • 1,4-Pentadien-3-one, 1-(4-hydroxy-3-methoxyphenyl)-5-(3,5,6-trimethyl-2-pyrazinyl)-, (1E,4E)-
  • 1881270-27-4