GSK-J2 (sodium salt)

Product Name: GSK-J2 (sodium salt)
CAS No.: 2108665-15-0
Chemical Name: GSK-J2 (sodium salt)
Synonyms: GSK-J2 (sodium salt);3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt
CBNumber: CB64666440
Molecular Formula: C22H24N5NaO2
Formula Weight: 413.46
MOL File: 2108665-15-0.mol

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GSK-J2 (sodium salt) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 50mg
Price: $936
Updated: 2024/03/01

AK Scientific

Product number: 1438EN
Product name: CID137699749
Packaging: 50mg
Price: $1139
Updated: 2021/12/16

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GSK-J2 (sodium salt) Chemical Properties,Usage,Production

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.^1,2 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC₅₀ > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.³ For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 and GSK-J5 , respectively. See the Structural Genomics Consortium (SGC) website for more information.

References

1. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449(7163),731-734(2011).
2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation Cold Spring Harb. Symp. Quant. Biol. 75,43-49(2010).
3. Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488,404-408(2012).

GSK-J2 (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-J2 (sodium salt) Suppliers

China 13 United States 2 Global 15

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11975
Advantage: 58

2108665-15-0, GSK-J2 (sodium salt)Related Search:

GSK-J2 (sodium salt)

3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt

2108665-15-0

C22H23N5O2HNa