GSK-J2 (sodium salt)

Product Name: GSK-J2 (sodium salt)
CAS No.: 2108665-15-0
Chemical Name: GSK-J2 (sodium salt)
Synonyms: GSK-J2 sodium;GSK-J2 (sodium salt);3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt
CBNumber: CB64666440
Molecular Formula: C22H24N5NaO2
Formula Weight: 413.46
MOL File: 2108665-15-0.mol

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GSK-J2 (sodium salt) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 12056
Product name: GSK-J2 (sodium salt)
Purity: ≥90%
Packaging: 50mg
Price: $936
Updated: 2024/03/01

AK Scientific

Product number: 1438EN
Product name: CID137699749
Packaging: 50mg
Price: $1139
Updated: 2021/12/16

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GSK-J2 (sodium salt) Chemical Properties,Usage,Production

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.^1,2 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC₅₀ > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.³ For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 and GSK-J5 , respectively. See the Structural Genomics Consortium (SGC) website for more information.

Uses

GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A[1].

References

1. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449(7163),731-734(2011).
2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation Cold Spring Harb. Symp. Quant. Biol. 75,43-49(2010).
3. Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488,404-408(2012).

GSK-J2 (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-J2 (sodium salt) Suppliers

China 17 United States 2 Global 19

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29357
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Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Guangzhou Qiansheng Biotechnology Co., Ltd.

Tel: 14748676110
Country: CHINA
ProdList: 112
Advantage: 58

2108665-15-0, GSK-J2 (sodium salt)Related Search:

GSK-J2 (sodium salt)

3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt

GSK-J2 sodium

2108665-15-0

C22H23N5O2HNa