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GSK-J2 (sodium salt)

Product Name
GSK-J2 (sodium salt)
CAS No.
2108665-15-0
Chemical Name
GSK-J2 (sodium salt)
Synonyms
GSK-J2 (sodium salt);3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt
CBNumber
CB64666440
Molecular Formula
C22H24N5NaO2
Formula Weight
413.46
MOL File
2108665-15-0.mol
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GSK-J2 (sodium salt) Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
12056
Product name
GSK-J2 (sodium salt)
Purity
≥90%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
12056
Product name
GSK-J2 (sodium salt)
Purity
≥90%
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
12056
Product name
GSK-J2 (sodium salt)
Purity
≥90%
Packaging
10mg
Price
$223
Updated
2024/03/01
Cayman Chemical
Product number
12056
Product name
GSK-J2 (sodium salt)
Purity
≥90%
Packaging
50mg
Price
$936
Updated
2024/03/01
AK Scientific
Product number
1438EN
Product name
CID137699749
Packaging
50mg
Price
$1139
Updated
2021/12/16
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GSK-J2 (sodium salt) Chemical Properties,Usage,Production

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.1,2 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.3 For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 and GSK-J5 , respectively. See the Structural Genomics Consortium (SGC) website for more information.

References

1. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449(7163),731-734(2011).
2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation Cold Spring Harb. Symp. Quant. Biol. 75,43-49(2010).
3. Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488,404-408(2012).

GSK-J2 (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-J2 (sodium salt) Suppliers

China 13 United States 2 Global 15
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

2108665-15-0, GSK-J2 (sodium salt)Related Search:


  • GSK-J2 (sodium salt)
  • 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt
  • 2108665-15-0
  • C22H23N5O2HNa