C18 3'-sulfo Galactosylceramide (d18:1/18:0)
- Product Name
- C18 3'-sulfo Galactosylceramide (d18:1/18:0)
- CAS No.
- 244215-65-4
- Chemical Name
- C18 3'-sulfo Galactosylceramide (d18:1/18:0)
- Synonyms
- N-Octadecanoyl-sulfatide;-sulfo Galactosylceramide (d18:1/18:0);C18 3'-sulfo Galactosylceramide (d18:1/18:0);N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-octadecanamide;Octadecanamide, N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-
- CBNumber
- CB64666970
- Molecular Formula
- C42H81NO11S
- Formula Weight
- 808.16
- MOL File
- 244215-65-4.mol
C18 3'-sulfo Galactosylceramide (d18:1/18:0) Property
- storage temp.
- Store at -20°C
- solubility
- Chloroform:Methanol (5:1): soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 24863
- Product name
- C18 3'-sulfo Galactosylceramide (d18:1/18:0)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $486
- Updated
- 2024/03/01
C18 3'-sulfo Galactosylceramide (d18:1/18:0) Chemical Properties,Usage,Production
Description
C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is a minor endogenous sphingolipid produced from C18 ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus.1 C18 3'-sulfo Galactosylceramide levels are increased in brain tissue isolated from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions.2,3 Plasma levels of C18 3’-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale.4 It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).5 Brain levels of short-chain sulfatides, including C18 3’-sulfo galactosylceramide, decrease with age in mice and humans.2,6 As this product is derived from a natural source, there may be variations in the sphingoid backbone.
Definition
ChEBI: 3-O-Sulfogalactosylceramide (d18:1/18:0) is a glycosphingolipid.
References
1. Takahashi, T., and Suzuki, T. Role of sulfatide in normal and pathological cells and tissues J. Lipid Res. 53(8),1437-1450(2012).
2. Isaac, G., Pernber, Z., Gieselmann, V., et al. Sulfatide with short fatty acid dominates in astrocytes and neurons FEBS J. 273(8),1782-1790(2006).
3. Moyano, A.L., Li, G., Lopez-Rosas, A., et al. Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-
4. Moyano, A.L., Pituch, K., Li, G., et al. Levels of plasma sulfatides C18 : 0 and C24 : 1 correlate with disease status in relapsing-
5. Saville, J.T., Smith, N.J.C., Fletcher, J.M., et al. Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophy Anal. Chim. Acta 955,79-85(2017).
6. Svennerholm, L., and St?llberg-Stenhagen, S. Changes in the fatty acid composition of cerebrosides and sulfatides of human nervous tissue with age J. Lipid Res. 9(2),215-225(1968).
C18 3'-sulfo Galactosylceramide (d18:1/18:0) Preparation Products And Raw materials
Raw materials
Preparation Products
C18 3'-sulfo Galactosylceramide (d18:1/18:0) Suppliers
- Tel
- 0717-6449896 13886658719
- Fax
- 0717-6558598
- root@zhongyitai.com
- Country
- China
- ProdList
- 1977
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9804
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12065
- Advantage
- 58