BMS-955176

Product Name: BMS-955176
CAS No.: 1392312-45-6
Chemical Name: BMS-955176
Synonyms: GSK3532795;BMS-955176;BMS-955176(free base);GSK-3532795,GSK3532795;BMS-955176 (GSK-3532795;Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]-
CBNumber: CB64667669
Molecular Formula: C42H62N2O4S
Formula Weight: 691.02
MOL File: 1392312-45-6.mol

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BMS-955176 Property

Boiling point:: 780.7±60.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
solubility: DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
pka: 4.36±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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BMS-955176 Chemical Properties,Usage,Production

Uses

GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC50s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively[1].

IC 50

HIV-1

References

[1] Regueiro-Ren A, et al. Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176). J Med Chem. 2018 Aug 23;61(16):7289-7313. DOI:10.1021/acs.jmedchem.8b00854

BMS-955176 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-955176 Suppliers

China 11 United States 4 Global 15

BOC Sciences

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TargetMol Chemicals Inc.

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RD International Technology Co., Limited

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1392312-45-6, BMS-955176Related Search:

BMS-955176

BMS-955176 (GSK-3532795

GSK3532795

BMS-955176(free base)

GSK-3532795,GSK3532795

Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]-

1392312-45-6