ChemicalBook > CAS DataBase List > MF-094
MF-094
- Product Name
- MF-094
- CAS No.
- 2241025-68-1
- Chemical Name
- MF-094
- Synonyms
- MF-094;MF-094, 10 mM in DMSO;MF094,Deubiquitinase,MF-094,MF 094,inhibit,DUBs,Inhibitor;(S)-N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide;Benzenepropanamide, α-[(cyclohexylcarbonyl)amino]-N-[5-[[(1,1-dimethylethyl)amino]sulfonyl]-1-naphthalenyl]-, (αS)-
- CBNumber
- CB64668176
- Molecular Formula
- C30H37N3O4S
- Formula Weight
- 535.7
- MOL File
- 2241025-68-1.mol
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MF-094 Property
- Density
- 1.229±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (233.34 mM)
- form
- Solid
- pka
- 11.96±0.50(Predicted)
- color
- Light yellow to yellow
- InChIKey
- DQXORJHBZHLLTE-SANMLTNESA-N
- SMILES
- [S](=O)(=O)(NC(C)(C)C)c1c2c(c(ccc2)NC(=O)[C@@H](NC(=O)C4CCCCC4)Cc3ccccc3)ccc1
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Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2501
- Product name
- MF-094
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $88.2
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML2501
- Product name
- MF-094
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $357
- Updated
- 2025/07/31
ChemScene
- Product number
- CS-0046060
- Product name
- MF-094
- Purity
- 98.96%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0046060
- Product name
- MF-094
- Purity
- 98.96%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0046060
- Product name
- MF-094
- Purity
- 98.96%
- Packaging
- 50mg
- Price
- $2250
- Updated
- 2021/12/16
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MF-094 Chemical Properties,Usage,Production
Uses
MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy[1].
Biological Activity
MF-094 is a potent inhibitor of ubiquitin specific protease 30 (USP30), a de-ubiquitinating enzymes (DUB) th at opposes the action of parkin-mediated ubiquitination in clearing damaged mitochondria. MF-094 is selective for USP30 with an IC50 value of 120 nM, compared to >10 μM for USPs 1, 8, and 9.
References
[1] Kluge AF, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659. DOI:10.1016/j.bmcl.2018.05.013
MF-094 Preparation Products And Raw materials
Raw materials
Preparation Products
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MF-094 Suppliers
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- 18149758185 18149758185;
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- China
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