THAL-SNS-032

ChemicalBook > CAS DataBase List > THAL-SNS-032

Product Name: THAL-SNS-032
CAS No.: 2139287-33-3
Chemical Name: THAL-SNS-032
Synonyms: SNS-THAL-032;THAL-SNS-032;THAL SNS 032,inhibit,PROTACs,CDK,THALSNS032,Cyclin dependent kinase,Inhibitor;N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide;1-Piperidineacetamide, 4-[[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-
CBNumber: CB64668606
Molecular Formula: C40H52N8O10S2
Formula Weight: 869.02
MOL File: 2139287-33-3.mol

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THAL-SNS-032 Property

Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C, stored under nitrogen
solubility: DMSO : 100 mg/mL (115.07 mM; Need ultrasonic)
pka: 7.86±0.70(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: BXDZOYLPNAIDOC-UHFFFAOYSA-N
SMILES: N1(CC(NCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=O)CCC(C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)=O)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2686
Product name: THAL-SNS-032
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2686
Product name: THAL-SNS-032
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $420
Updated: 2024/03/01

Tocris

Product number: 6532
Product name: THALSNS032
Purity: ≥98%(HPLC)
Packaging: 5
Price: $378
Updated: 2021/12/16

TRC

Product number: T430133
Product name: THALSNS032
Packaging: 2.5mg
Price: $760
Updated: 2021/12/16

ChemScene

Product number: CS-0087538
Product name: THAL-SNS-032
Purity: 99.16%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

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THAL-SNS-032 Chemical Properties,Usage,Production

Description

THAL-SNS-032 is a selective CDK9 degrader PROTAC composed of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Uses

THAL SNS 032 is a potent, selective and cereblon-dependent degrader of CDK9 (EC50 = 4 nM). Displays >15-fold selectivity for CDK9 over other CDKs (EC50 values are 62, 171 and 398 nM for CDK2, CDK1 and CDK7, respectively). Induces complete degradation of CDK9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines.

Biological Activity

THAL-SNS-032, a small molecule formed by conjugating the multi-targeting kinase inhibitor SNS-032 to thalidomide, induced potent and selective degradation of CDK9 in a CRBN-dependent fashion. Treatment with THAL-SNS-032 resulted in selective degradation of CDK9 with limited effects on the protein level of other CDKs. Furthermore, THAL-SNS-032 had a prolonged pharmacodynamic effect compared with traditional kinase inhibitors. The antitumoral activity of THAL-SNS-032 in cell lines expressing ER or both ER and HER2, including luminal A cells, has been demonstrated[1-2].

storage

Store at -20°C

References

[1] Calla M Olson. “Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.” Nature chemical biology 14 2 (2017): 163–170.
[2] María Del Mar Noblejas-López. “Antitumoral Activity of a CDK9 PROTAC Compound in HER2-Positive Breast Cancer.” International Journal of Molecular Sciences 23 10 (2022).

THAL-SNS-032 Preparation Products And Raw materials

Raw materials

Preparation Products

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THAL-SNS-032 Suppliers

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View Lastest Price from THAL-SNS-032 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: THAL-SNS-032 2139287-33-3
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 500mg
Release date: 2021-08-26

Hubei Chuchang Biotech Co., Ltd.

Product: THAL-SNS-032 2139287-33-3
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98%+ HPLC
Supply Ability: 50g per month
Release date: 2024-03-28

2139287-33-3, THAL-SNS-032Related Search:

THAL-SNS-032

N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

1-Piperidineacetamide, 4-[[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-

SNS-THAL-032

THAL SNS 032,inhibit,PROTACs,CDK,THALSNS032,Cyclin dependent kinase,Inhibitor

2139287-33-3

C40H52N8O10S2