PFM01

Product Name: PFM01
CAS No.: 1558598-41-6
Chemical Name: PFM01
Synonyms: PFM01;PFM01 >=98% (HPLC);(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
CBNumber: CB64670537
Molecular Formula: C14H15NO2S2
Formula Weight: 293.4
MOL File: 1558598-41-6.mol

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PFM01 Property

Boiling point:: 435.2±55.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
pka: 8.59±0.30(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1735
Product name: PFM01
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1735
Product name: PFM01
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

Tocris

Product number: 6222
Product name: PFM01
Purity: ≥98%(HPLC)
Packaging: 50
Price: $315
Updated: 2021/12/16

Tocris

Product number: 6222
Product name: PFM01
Purity: ≥98%(HPLC)
Packaging: 10
Price: $75
Updated: 2021/12/16

TRC

Product number: P293993
Product name: PFM01
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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PFM01 Chemical Properties,Usage,Production

Biochem/physiol Actions

PFM01 is a cell-permeable N-alkylated Mirin (Sigma Cat. No. 475954) derivative that selectively inhibits against MRE11 endo-, but not exo-, nuclease activity. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. While both endonuclease and exonuclease activities are required for MRE11-mediated homologous recombination (HR) repair, only FM01 (100 μM), but not the exonuclease inhibitors Mirin (500 μM) and PFM39 (100 μM), rescues G2-phase double-strand break (DSB) repair defect in HR protein BRCA2-deficient HSC62-hTERT fibroblasts following ionizing irradiation (IR) by blocking HR initiation and thereby allowing non-homologous end joining (NHEJ) to proceed.

storage

Store at -20°C

PFM01 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFM01 Suppliers

China 23 United Kingdom 1 United States 8 USA 1 Global 33

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1558598-41-6, PFM01Related Search:

PFM01

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

PFM01 >=98% (HPLC)

(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one

Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit

4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-

1558598-41-6