ChemicalBook > CAS DataBase List > UPCDC30245

UPCDC30245

Product Name
UPCDC30245
CAS No.
1883351-01-6
Chemical Name
UPCDC30245
Synonyms
UPCDC30245;UPCDC30245 >=98% (HPLC);1-Piperazineethanamine, N-[1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-4-piperidinyl]-4-(1-methylethyl)-
CBNumber
CB64670658
Molecular Formula
C28H38FN5
Formula Weight
463.63
MOL File
1883351-01-6.mol
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UPCDC30245 Property

Boiling point:
647.6±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 30mg/mL, clear
form 
powder
pka
16.22±0.30(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1674
Product name
UPCDC30245
Purity
≥98% (HPLC)
Packaging
5MG
Price
$131.1
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1674
Product name
UPCDC30245
Purity
≥98% (HPLC)
Packaging
25MG
Price
$558
Updated
2025/07/31
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UPCDC30245 Chemical Properties,Usage,Production

Uses

UPCDC-30245 is an allosteric p97 inhibitor with an IC50 of approximately 27 nM[1]. UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC50=300 nM) and shows 3-fold resistance for p97 mutant T688A[2]. UPCDC-30245 can be used in the research of cancer[1][2][3].

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50 value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

IC 50

allosteric p97: 27 nM (IC50); wild type p97: 300 nM (IC50)

References

[1] Banerjee S, et al. 2.3 ? resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016 Feb 19;351(6275):871-5. DOI:10.1126/science.aad7974
[2] Wang F, et al. Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy. ChemMedChem. 2020 Apr 20;15(8):685-694. DOI:10.1002/cmdc.201900722
[3] Wang F, et al. Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition. Cell Chem Biol. 2021 Nov 23:S2451-9456(21)00482-7. DOI:10.1016/j.chembiol.2021.11.005

UPCDC30245 Preparation Products And Raw materials

Raw materials

Preparation Products

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UPCDC30245 Suppliers

China 13 United States 1 Global 14
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
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13816107857
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qq: 276312098
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sales@fortunechem-sh.com
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Shanghai Beckham Medical Technology Co., Ltd
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13816613772
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QQ: 12922499
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huahero21@sina.com
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China
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
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China
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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China
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44894
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Beijing Biocreative Technology Co., Ltd.
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15522676233
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3007606172@qq.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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China
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Merck KGaA
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21-20338288
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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Lucheng (Shenzhen) Technology Co., Ltd.
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13128698830
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Biorbyt Ltd.
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1883351-01-6, UPCDC30245Related Search:


  • UPCDC30245
  • UPCDC30245 >=98% (HPLC)
  • 1-Piperazineethanamine, N-[1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-4-piperidinyl]-4-(1-methylethyl)-
  • 1883351-01-6