ChemicalBook > CAS DataBase List > Risdiplam
Risdiplam
- Product Name
- Risdiplam
- CAS No.
- 1825352-65-5
- Chemical Name
- Risdiplam
- Synonyms
- RG7916;2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;Lispran;RO7034067;Risdiplam;Risdiplam (RG7916);Risdiplam (RG7916) ，S6925;Risdiplam (RG-7916, RO-7034067);7-amino-2,3-dihydro-1H-inden-4-ol;RG 7916,Inhibitor,RG-7916,Risdiplam,RO 7034067,DNA/RNA Synthesis,RO-7034067,inhibit
- CBNumber
- CB64674494
- Molecular Formula
- C22H23N7O
- Formula Weight
- 401.46
- MOL File
- 1825352-65-5.mol
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Risdiplam Property
- Density
- 1.50±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO
- pka
- 9.41±0.20(Predicted)
- form
- solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3
- InChIKey
- ASKZRYGFUPSJPN-UHFFFAOYSA-N
- SMILES
- C12C=CC(N3CC4(CC4)NCC3)=CN1C(=O)C=C(C1=NN3C=C(C)N=C3C(C)=C1)N=2
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29028
- Product name
- Risdiplam
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29028
- Product name
- Risdiplam
- Packaging
- 25mg
- Price
- $353
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29028
- Product name
- Risdiplam
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29028
- Product name
- Risdiplam
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0039501
- Product name
- Risdiplam
- Purity
- 99.35%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
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Risdiplam Chemical Properties,Usage,Production
Description
Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.
Chemical Properties
light yellow powder to yellow powder
Uses
Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.
Mechanism of action
Risdiplam works by modifying the splicing process of the SMN2 gene, increasing the production of full-length and functional SMN protein.
Side effects
Body aches or pain, chest pain or tightness, chills, cough, ear congestion, fever, headache, loss of voice, runny or stuffy nose, sneezing, sore throat, trouble breathing, unusual tiredness or weakness and so on.
Synthesis
SNAr reaction between amine 194 and bromopyridine 195 gave 196 in good yield. Reduction by hydrogenation in the presence of a platinum catalyst followed by treatment with di-tert-butyl malonate gave pyridopyrimidone 197 in benzoxazole at elevated temperature in good overall yield for both steps. Mesylation to form sulfonate 198 then participated in a Suzuki coupling with 200 (derived from aryl chloride 199 via Miyaura coupling) to establish the risdiplam core skeleton. N-Boc deprotection of 201 using hydrochloric acid in isopropanol gave risdiplam (XXVI) which was isolated after pH adjustment.
storage
0-4℃ for short term (days to weeks) or -20℃ for long term (months)
Risdiplam Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Risdiplam manufacturers
Shaanxi Didu New Materials Co. Ltd
- Product
- Risdiplam 1825352-65-5
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 1 kg
- Release date
- 2025-04-03
Hebei Yanxi Chemical Co., Ltd.
- Product
- Risdiplam 1825352-65-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-08
Apeloa production Co.,Limited
- Product
- Risdiplam 1825352-65-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000
- Release date
- 2024-06-05