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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide

Product Name
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
CAS No.
824960-50-1
Chemical Name
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
Synonyms
WDR5-0102;WDR5-0102, 10 mM in DMSO;2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide;Benzamide, 2-chloro-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-
CBNumber
CB64695376
Molecular Formula
C18H19ClN4O3
Formula Weight
374.82
MOL File
824960-50-1.mol
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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Property

Boiling point:
474.4±45.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
pka
11.67±0.70(Predicted)
form 
Solid
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Chemical Properties,Usage,Production

Uses

WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].

References

[1] Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. DOI:10.1016/j.bmcl.2018.12.035
[2] Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556. DOI:10.1021/acs.jmedchem.1c00037

2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Suppliers

China 14 United States 1 Global 15
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
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022-23754520
Email
klq@cw-bio.com
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China
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8011
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Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
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9125
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Shanghai ruichang pharmaceutical technology co., LTD
Tel
18621054990
Email
maychemicals@sina.com
Country
China
ProdList
673
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
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59936
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
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China
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11973
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58
Hubei wei shi reagent group ltd., company
Tel
027-59101766 13125137661
Email
2853877621@qq.com
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China
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7979
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58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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025-58851090 17714375163
Email
2881759498@qq.com
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China
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13011
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58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
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58

824960-50-1, 2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamideRelated Search:


  • 2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
  • Benzamide, 2-chloro-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-
  • WDR5-0102
  • WDR5-0102, 10 mM in DMSO
  • 824960-50-1