ChemicalBook > CAS DataBase List > 2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
- Product Name
- 2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
- CAS No.
- 824960-50-1
- Chemical Name
- 2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
- Synonyms
- WDR5-0102;WDR5-0102, 10 mM in DMSO;2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide;Benzamide, 2-chloro-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-
- CBNumber
- CB64695376
- Molecular Formula
- C18H19ClN4O3
- Formula Weight
- 374.82
- MOL File
- 824960-50-1.mol
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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Property
- Boiling point:
- 474.4±45.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- pka
- 11.67±0.70(Predicted)
- form
- Solid
- color
- Light brown to brown
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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Chemical Properties,Usage,Production
Uses
WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].
References
[1] Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. DOI:10.1016/j.bmcl.2018.12.035
[2] Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556. DOI:10.1021/acs.jmedchem.1c00037
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide Suppliers
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