GK187 Property

Boiling point:

330.3±42.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);96.69(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.97(Max Conc. mM)

form 

Liquid

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

GK187 Chemical Properties,Usage,Production

Description

GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A₂ (iPLA₂), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA₂ by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA₂ over GIVA cPLA₂ and GV sPLA₂ where it shows less than 25% and 32.8% inhibition, respectively.

Uses

GK187 is a very potent and selective GVIA iPLA2 inhibitor.