GS 143

Product Name: GS 143
CAS No.: 916232-21-8
Chemical Name: GS 143
Synonyms: GS 143;4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid;Benzoic acid, 4-[4-[[5-(2-fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]-;E2 conjugating enzyme,inhibit,IκBα,Th2,Ubiquitin conjugating enzyme,GS143,Ubiquitin ligase,IL-4,IκB kinase,βTrCP1,Nuclear factor-kappaB,eosinophil,Ubiquitin activating enzyme,Nuclear factor-κB,I kappa B kinase,NF-κB,E3 ligating enzyme,IKK,E1 activating enzyme,anti-asthma,E1/E2/E3 Enzyme,ubiquitination,Inhibitor,airway,inflammation
CBNumber: CB64721604
Molecular Formula: C28H19FN2O4
Formula Weight: 466.46
MOL File: 916232-21-8.mol

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GS 143 Property

Boiling point:: 667.9±65.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:25.0(Max Conc. mg/mL);53.59(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.43(Max Conc. mM)
DMSO:31.38(Max Conc. mg/mL);67.28(Max Conc. mM)
form: A crystalline solid
pka: 4.20±0.10(Predicted)
color: Pink to red

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26138
Product name: GS-143
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 26138
Product name: GS-143
Packaging: 50mg
Price: $672
Updated: 2024/03/01

Cayman Chemical

Product number: 26138
Product name: GS-143
Packaging: 10mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 26138
Product name: GS-143
Packaging: 25mg
Price: $388
Updated: 2024/03/01

Tocris

Product number: 5636
Product name: GS143
Purity: ≥98%(HPLC)
Packaging: 10
Price: $182
Updated: 2021/12/16

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GS 143 Chemical Properties,Usage,Production

Uses

4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]-benzoic Acid blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells.

storage

Store at +4°C

GS 143 Preparation Products And Raw materials

Raw materials

Preparation Products

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GS 143 Suppliers

China 20 Japan 1 United Kingdom 1 United States 5 USA 1 Global 28

916232-21-8, GS 143Related Search:

GS-441524 GS-4361

GS 143

4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid

4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

E2 conjugating enzyme,inhibit,IκBα,Th2,Ubiquitin conjugating enzyme,GS143,Ubiquitin ligase,IL-4,IκB kinase,βTrCP1,Nuclear factor-kappaB,eosinophil,Ubiquitin activating enzyme,Nuclear factor-κB,I kappa B kinase,NF-κB,E3 ligating enzyme,IKK,E1 activating enzyme,anti-asthma,E1/E2/E3 Enzyme,ubiquitination,Inhibitor,airway,inflammation

Benzoic acid, 4-[4-[[5-(2-fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]-

916232-21-8