ITH 12575

Product Name: ITH 12575
CAS No.: 1802013-08-6
Chemical Name: ITH 12575
Synonyms: ITH 12575;ITH12575,ITH 12575;ITH12575 >=98% (HPLC);7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one;4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-
CBNumber: CB64731339
Molecular Formula: C18H18ClNOS
Formula Weight: 331.86
MOL File: 1802013-08-6.mol

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ITH 12575 Property

Boiling point:: 484.5±45.0 °C(Predicted)
Density: 1.219±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.34±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5692
Product name: ITH12575
Purity: ≥98%(HPLC)
Packaging: 10
Price: $207
Updated: 2021/12/16

Tocris

Product number: 5692
Product name: ITH12575
Purity: ≥98%(HPLC)
Packaging: 50
Price: $873
Updated: 2021/12/16

TRC

Product number: C374793
Product name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Packaging: 1mg
Price: $70
Updated: 2021/12/16

TRC

Product number: C374793
Product name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Packaging: 5mg
Price: $320
Updated: 2021/12/16

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ITH 12575 Chemical Properties,Usage,Production

Uses

7-?Chloro-?1,?5-?dihydro-?5-?[2-?(1-?methylethyl)?phenyl]?-4,?1-benzothiazepin-?2(3H)?-?one can be used to study the physiological roles of the mitochondrial sodium /calcium exchanger related to neurodegeneration.

Biological Activity

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. at higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel th at plays a key role in the neuronal electrical activity.

storage

Store at RT

ITH 12575 Preparation Products And Raw materials

Raw materials

Preparation Products

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ITH 12575 Suppliers

China 8 Japan 1 United Kingdom 1 United States 2 USA 1 Global 13

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5960
Advantage: 55

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5127
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Email: rdname@qq.com
Country: China
ProdList: 35705
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

1802013-08-6, ITH 12575Related Search:

ITH 12575

7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one

ITH12575 >=98% (HPLC)

ITH12575,ITH 12575

4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-

1802013-08-6