ChemicalBook > CAS DataBase List > ITH 12575
ITH 12575
- Product Name
- ITH 12575
- CAS No.
- 1802013-08-6
- Chemical Name
- ITH 12575
- Synonyms
- ITH 12575;ITH12575,ITH 12575;ITH12575 >=98% (HPLC);7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one;4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-
- CBNumber
- CB64731339
- Molecular Formula
- C18H18ClNOS
- Formula Weight
- 331.86
- MOL File
- 1802013-08-6.mol
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ITH 12575 Property
- Boiling point:
- 484.5±45.0 °C(Predicted)
- Density
- 1.219±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.34±0.40(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Tocris
- Product number
- 5692
- Product name
- ITH12575
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $207
- Updated
- 2021/12/16
Tocris
- Product number
- 5692
- Product name
- ITH12575
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $873
- Updated
- 2021/12/16
TRC
- Product number
- C374793
- Product name
- 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
TRC
- Product number
- C374793
- Product name
- 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
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ITH 12575 Chemical Properties,Usage,Production
Uses
7-?Chloro-?1,?5-?dihydro-?5-?[2-?(1-?methylethyl)?phenyl]?-4,?1-benzothiazepin-?2(3H)?-?one can be used to study the physiological roles of the mitochondrial sodium /calcium exchanger related to neurodegeneration.
Biological Activity
ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. at higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel th at plays a key role in the neuronal electrical activity.
storage
Store at RT
ITH 12575 Preparation Products And Raw materials
Raw materials
Preparation Products
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ITH 12575 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77